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- Publications
- Influence
Chemical cytometry: fluorescence-based single-cell analysis.
- D. Cohen, Jane A. Dickerson, +4 authors N. Dovichi
- Biology, Medicine
- Annual review of analytical chemistry
- 13 June 2008
Cytometry deals with the analysis of the composition of single cells. Flow and image cytometry employ antibody-based stains to characterize a handful of components in single cells. Chemical… Expand
Metabolic cytometry. Glycosphingolipid metabolism in single cells.
- Colin D. Whitmore, O. Hindsgaul, M. Palcic, R. Schnaar, N. Dovichi
- Chemistry, Medicine
- Analytical chemistry
- 14 June 2007
Glycosphingolipids are found on all vertebrate cells and constitute major cell surface determinants on all nerve cells, where they contribute to cellular diversity and function. We report a method… Expand
Yoctomole analysis of ganglioside metabolism in PC12 cellular homogenates
- Colin D. Whitmore, U. Olsson, E. Larsson, O. Hindsgaul, M. Palcic, N. Dovichi
- Chemistry, Medicine
- Electrophoresis
- 1 September 2007
We report an ultrasensitive method for the analysis of glycosphingolipid catabolism. The substrate GM1 and the set of seven metabolites into which it can be degraded (GA1, GM2, GA2, GM3, LacCer,… Expand
Instrumentation for medium-throughput two-dimensional capillary electrophoresis with laser-induced fluorescence detection.
- Cuiru Zhu, X. He, +7 authors N. Dovichi
- Chemistry, Medicine
- Analytical chemistry
- 15 January 2007
In two-dimensional capillary electrophoresis, a sample undergoes separation in the first dimension capillary by sieving electrophoresis. Fractions are periodically transferred across an interface… Expand
Capillary electrophoresis‐mass spectrometry methods for tryptic peptide mapping of therapeutic antibodies
- Colin D. Whitmore, L. Gennaro
- Chemistry, Medicine
- Electrophoresis
- 1 June 2012
Tryptic peptide mapping is routinely used in the biotech industry to confirm primary sequence, cell line stability, and to analyze posttranslational modifications. Peptide analysis is generally done… Expand
Six orders of magnitude dynamic range in capillary electrophoresis with ultrasensitive laser-induced fluorescence detection.
- Colin D. Whitmore, David C. Essaka, N. Dovichi
- Chemistry, Medicine
- Talanta
- 15 December 2009
An ultrasensitive laser-induced fluorescence detector was used with capillary electrophoresis for the study of 5-carboxy-tetramethylrhodamine. The raw signal from the detector provided roughly three… Expand
Synthesis of reference standards to enable single cell metabolomic studies of tetramethylrhodamine-labeled ganglioside GM1.
- E. Larsson, U. Olsson, +6 authors O. Hindsgaul
- Chemistry, Medicine
- Carbohydrate research
- 26 February 2007
Ganglioside GM1 and its seven potential catabolic products: asialo-GM1, GM2, asialo-GM2, GM3, Lac-Cer, Glc-Cer and Cer, were labeled with tetramethylrhodamine (TMR) to permit ultra-sensitive analysis… Expand
CE‐MALDI interface based on inkjet technology
- M. Vannatta, Colin D. Whitmore, N. Dovichi
- Chemistry, Medicine
- Electrophoresis
- 1 December 2009
An ink jet printer valve and a nozzle were used to deliver matrix and sample from an electrophoresis capillary onto a MALDI plate. The system was evaluated by the separation of a set of standard… Expand
Monitoring the uptake of glycosphingolipids in Plasmodium falciparum-infected erythrocytes using both fluorescence microscopy and capillary electrophoresis with laser-induced fluorescence detection.
- David C. Essaka, J. White, +4 authors N. Dovichi
- Chemistry, Medicine
- Analytical chemistry
- 1 December 2010
The metabolism of glycosphingolipids by the malaria-causing parasite Plasmodium falciparum plays an important role in the progression of the disease. We report a new and highly sensitive method to… Expand
Interface of an array of five capillaries with an array of one-nanoliter wells for high-resolution electrophoretic analysis as an approach to high-throughput chemical cytometry.
- Anna K. Boardman, Sarah C. McQuaide, Cuiru Zhu, Colin D. Whitmore, M. Lidstrom, N. Dovichi
- Chemistry, Medicine
- Analytical chemistry
- 22 August 2008
We report a system that allows the simultaneous aspiration of one or more cells into each of five capillaries for electrophoresis analysis. A glass wafer was etched to create an array of 1-nL wells.… Expand
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