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Finite strain analyses of the left ventricle provide important information on heart function and have the potential to provide insights into the biomechanics of myocardial contractility in health and disease. Systolic dysfunction is the most common cause of heart failure; however, abnormalities of diastolic function also contribute to heart failure, and are(More)
Finite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress toward dynamic patient-specific models of the left ventricle using an immersed boundary (IB) method with a finite element (FE) structural mechanics model. We use a structure-based hyperelastic(More)
Detailed models of the biomechanics of the heart are important both for developing improved interventions for patients with heart disease and also for patient risk stratification and treatment planning. For instance, stress distributions in the heart affect cardiac remodelling, but such distributions are not presently accessible in patients. Biomechanical(More)
Chronic heart failure (CHF) is now recognized as a major and escalating public health problem. The costs of this syndrome, both in economic and personal terms, are considerable. The prevalence of CHF is 1-2% and appears to be increasing, in part because of ageing of the population. Economic analyses of CHF should include both direct and indirect costs of(More)
In this work, we introduce a modified Holzapfel-Ogden hyperelastic constitutive model for ventricular myocardium that accounts for residual stresses, and we investigate the effects of residual stresses in diastole using a magnetic resonance imaging-derived model of the human left ventricle (LV). We adopt an invariant-based constitutive modelling approach(More)
Keywords: Human mitral valve Clinical imaging Magnetic resonance imaging Fluid–structure interaction Immersed boundary method a b s t r a c t The mitral valve (MV) is one of the four cardiac valves. It consists of two leaflets that are connected to the left ventricular papillary muscles via multiple fibrous chordae tendinae. The primary functions of the MV(More)
BACKGROUND The relative merits of quantitative coronary analysis (QCA) and intravascular ultrasound (IVUS) for the assessment of progression/regression in coronary artery disease are uncertain. To explore this subject further, we analyzed the angiographic and IVUS data derived from a contemporary clinical trial population. METHODS AND RESULTS We(More)
A central problem in biomechanical studies of personalized human left ventricular (LV) modelling is to estimate material properties from in vivo clinical measurements. In this work we evaluate the passive myocardial mechanical properties inversely from the in vivo LV chamber pressure–volume and strain data. The LV myocardium is described using a(More)
BACKGROUND The pathophysiology of myocardial injury and repair in patients with ST-elevation myocardial infarction is incompletely understood. We investigated the relationships among culprit artery microvascular resistance, myocardial salvage, and ventricular function. METHODS AND RESULTS The index of microvascular resistance (IMR) was measured by means(More)
BACKGROUND The indications, complexity and capabilities of cardiovascular magnetic resonance (CMR) have rapidly expanded. Whether actual service provision and training have developed in parallel is unknown. METHODS We undertook a systematic telephone and postal survey of all public hospitals on behalf of the British Society of Cardiovascular Magnetic(More)