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Glucagon-like peptide-1 (GLP-1) is an intestinally derived insulinotropic hormone currently under investigation for use as a novel therapeutic agent in the treatment of type 2 diabetes mellitus. In(More)
The expression of the paracrine signaling hormone pituitary adenylate cyclase-activating polypeptide (PACAP) is regulated in a cyclical fashion during the 12-day spermatogenic cycle of the adult rat(More)
The disease diabetes mellitus arises as a consequence of a failure of the beta-cells in the islets of Langerhans of the pancreas to produce insulin in the amounts required to meet the needs of the(More)
THE HORMONAL ACTIVATION of cAMP production in pancreatic -cells is accompanied by an increase of cytosolic [cAMP] that can be measured in real time through the use of a cAMP sensor (Epac1-camps) that(More)