Cole Sterling

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BACKGROUND Symptomatic cavernous malformations involving the brainstem are difficult to access by conventional approaches, which often require dramatic brain retraction to gain adequate operative corridor. Here, we present a successful endoscopic endonasal transclival approach for resection of a hemorrhagic, symptomatic mesencephalic cavernous malformation.(More)
The effects of epileptiform bursts on hippocampal excitability were examined in the CA3 region of guinea-pig hippocampal slices. Partial blockade of gamma-aminobutyric acidA (GABAA)-mediated inhibition by 500 IU/ml penicillin produced low frequency (2-4 Hz) "pro-convulsant" field potential oscillations. Normal spontaneous activity recovered less than 30 min(More)
Inoculation of rats i.v. with dextran sulfate or polymethacrylic acid causes lymphocytosis. Electron microscopy of sections of cervical lymph nodes in control rats showed active passage of small lymphocytes through the high endothelial cells (HEC) of the post-capillary venules. In treated rats there was no indication of such passage: the HEC were free of(More)
Biphasic field potentials were recorded in the CA3 distal dendritic region in response to both antidromic (fornix) and orthodromic (mossy fiber) stimulation in guinea pig hippocampal slices in vitro. The positive component (P1) corresponded to intracellularly recorded excitatory postsynaptic potentials. The negative component (N1) appears to be due to(More)
We examined the role of N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors in generating spontaneous CA3 field potential oscillations in the hippocampal slice. Non-NMDA EPSPs are responsible for a portion of the spontaneous activity recorded in standard perfusion medium. NMDA receptors are not activated when inhibition is intact, however,(More)
Low concentrations of penicillin (50-300 IU/ml) produce a pro-convulsant state in CA3 hippocampus characterized by low amplitude, low frequency (2-3 Hz) spontaneous field potential oscillations. Evoked field potentials were used to demonstrate that this distinct, coordinated behavior of the hippocampal neuronal network which is intermediate between normal(More)
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