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To explore the hypothesis that load-induced fluid flow in bone is a mechano-transduction mechanism in bone adaptation, unit cell micro-mechanical techniques are used to relate the microstructure of Haversian cortical bone to its effective poroelastic properties. Computational poroelastic models are then applied to compute in vitro Haversian fluid flows in a(More)
Viscoelastic properties of wet and dry human compact bone were studied in torsion and in bending for both the longitudinal and transverse directions at frequencies from 5 mHz to 5 kHz in bending to more than 50 kHz in torsion. Two series of tests were done for different longitudinal and transverse specimens from a human tibia. Wet bone exhibited a larger(More)
Despite its widespread use as graft material in orthopaedic surgical procedures, morselized cancellous bone has not yet been well characterized from the standpoint of its mechanical properties. To accommodate the noncohesive nature of this loose particulate form of bone, a triaxial compression test apparatus commonly used in engineering soil mechanics was(More)
SUMMARY A framework alternative to that of classical slope stability analysis is developed, wherein the soil mass is treated as a continuum and in-situ soil stresses and strengths are computed accurately using inelastic "nite element methods with general constitutive models. Within this framework, two alternative methods of stability analysis are presented.(More)
SUMMARY A formulation for design of continuous, hinge-free compliant mechanisms is developed and examined within a continuum structural topology optimization framework. The formulation makes use of two distinctly different sets of springs, the first of which are artificial springs of relatively large stiffness attached to the input and output ports of the(More)
It is considered that asymmetrical material layout design solutions are caused by numerical roundo€ and the convexity characteristics of alternative topology design formulations. Emphasis is placed here not on analyzing potential instabilities that lead to asymmetrical designs, but on a method to stabilize topology design formulations. A novel symmetry(More)
Following a major outbreak of tuberculosis in cattle on a farm in Dorset, badgers were discovered to be infected with Mycobacterium bovis. Two hundred and forty sets were found in the 1200 hectares of the study area. The sets were found predominantly in areas of Portland Sand. A high prevalence of tuberculosis was found in the badger population which was(More)
To explore the potential role that load-induced fluid flow plays as a mechano-transduction mechanism in bone adaptation, a lacunar-canalicular scale bone poroelasticity model is developed and implemented. The model uses micromechanics to homogenize the pericanalicular bone matrix, a system of straight circular cylinders in the bone matrix through which bone(More)
A large sample of the wild mammals found on a farm in South Dorset were trapped and examined for the presence of Mycobacterium bovis following the discovery of widespread infection in cattle and badgers. M. bovis was isolated from the lymph nodes of two out of 90 rats (rattus norvegicus) and one out of seven foxes (Vulpes vulpes) but no lesions of(More)
The desired results of variable topology material layout computations are stable and discrete material distributions that optimize the performance of structural systems. To achieve such material layout designs a continuous topology design framework based on hybrid combinations of classical Reuss (compliant) and Voigt (stii) mixing rules is investigated. To(More)