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Dengue virus (DENV) is a mosquito-borne flavivirus that causes serious global human disease and mortality. Skin immune cells are an important component of initial DENV infection and systemic spread. Here, we show that mast cells are a target of DENV in human skin and that DENV infection of skin mast cells induces degranulation and alters cytokine and growth(More)
BACKGROUND Resveratrol, a natural polyphenol found in the skin of red grapes, is reported to have anti-inflammatory properties including protective effects against aging. Consequently, Resveratrol is a common nutritional supplement and additive in non-prescription lotions and creams marketed as anti-aging products. Studies in mice and with mouse bone(More)
TOXLINE is the National Library of Medicine's online bibliographic database covering the toxicologic, pharmacologic, biochemical, physiologic, and environmental effects of chemicals. It is a merged database composed of subsets from 13 different sources. Most of the citations in TOXLINE refer to journal articles; other publication types include meeting(More)
The effect of different qualities of ionizing radiation on the activity of brain enzymes involved in the metabolism of neurotransmitters in specific regions of the brain of rats was investigated. Groups of Sprague-Dawley adult male rats were exposed to approximately 20,000 rads of radiation either rich in neutrons or rich in gamma rays from the AFRRI-TRIGA(More)
The activities of liver enzymes involved in the breakdown and synthesis of glycogen have been investigated in rats exposed to 1200 rads midline kerma dose, freein-air, of x rays or mixed gamma-neutron radiation. It was found that glycogen phosphorylase and amylo-1, 6-glucosidase, both of which are involved in the breakdown of glycogen to "glucose" units,(More)