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Interferon-gamma (IFN-gamma) has some anti-tumour activity in human ovarian cancer. This cytokine inhibited proliferation in three of four ovarian cancer cell lines in vitro. We then compared the action of IFN-gamma in two cell lines, one sensitive and one resistant to its growth inhibitory effects. IFN-gamma signalling appeared normal in both cell lines,(More)
The cellular response, in terms of cell cycle arrest(s) and apoptosis, to radiation-induced DNA damage was studied. Experiments were performed on both mitogen-stimulated and resting peripheral blood lymphocytes (PBLs) from normal and cancer-prone (C-P) individuals. The C-P individuals comprised three patients carrying germline p53 mutations and three(More)
The aim of this study was to investigate mechanisms of anti-tumour activity and necrosis induced by combinations of tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma). In a breast cancer xenograft model, locally injected recombinant human TNF-alpha arrested growth of established tumours in the absence of overt necrosis. Macroscopic(More)
This study investigates data from the BBC Voices project which contains a large amount of vernacular data collected by the BBC between 2004 and 2005. This project was designed primarily to collect information on vernacular speech around the United Kingdom for broadcasting purposes. As part of the project, a web-based questionnaire was created, to which tens(More)
The volume we are introducing here contains a selection of the papers presented at a special track on computational techniques for studying language variation held at for their cooperation in our organisation of the event. We likewise owe thanks to the referees of the present volume, who we are pleased to acknowledge explicitly: The conference track(More)
In our earlier work, an approach to defining dialect areas using multidimensional scaling (MDS) of the total collection of available raw data has produced results that showed some but not all of the dialect distinctions that were anticipated. To investigate this situation, we have extended our approach in two ways, one methodological and one technical.(More)
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