Learn More
BACKGROUND The pharmacological management of violence in people with psychiatric disorders is under-researched. AIMS To compare interventions commonly used for controlling agitation or violence in people with serious psychiatric disorders. METHOD We randomised 200 people to receive intramuscular lorazepam (4 mg) or intramuscular haloperidol (10 mg) plus(More)
BACKGROUND Aripiprazole is an atypical antipsychotic that is reported to be effective in the treatment of schizophrenia. AIMS To investigate the effects of aripiprazole on patients with schizophrenia and schizophrenia-like psychoses by conducting a systematic review of randomised controlled trials (RCTs). METHOD Database and manual searches and direct(More)
BACKGROUND A recent review suggested an association between using unpublished scales in clinical trials and finding significant results. AIMS To determine whether such an association existed in schizophrenia trials. METHOD Three hundred trials were randomly selected from the Cochrane Schizophrenia Group's Register. All comparisons between treatment(More)
OBJECTIVE The purpose of this study was to evaluate all available trial-based evidence on the effectiveness of clozapine in schizophrenia as compared with conventional neuroleptics. METHOD All randomized, controlled trials comparing clozapine with a conventional neuroleptic in which there was satisfactory concealment of patients' treatment allocation were(More)
In the pragmatic-explanatory continuum, a randomized controlled trial (RCT) can at one extreme investigate whether a treatment could work in ideal circumstances (explanatory), or at the other extreme, whether it would work in everyday practice (pragmatic). How explanatory or pragmatic a study is can have implications for clinicians, policy makers, patients,(More)
BACKGROUND Long-acting depot antipsychotic medication is a widely used treatment for schizophrenia. AIMS To synthesise relevant systematic Cochrane reviews. METHOD The Cochrane Database was searched and summary data were extracted from randomised controlled clinical trials of depots. RESULTS Standard dose depot v. placebo resulted in significantly(More)
OBJECTIVE The randomized trial provides an opportunity to minimize the inclusion of biases in the evaluation of interventions in psychiatry. Difficulties arise, however, when applying their results to 'real world' clinical practice and decision-making. We, therefore, examined the real world applicability of schizophrenia trials. METHOD A narrative(More)
High quality, cost-effective medical care requires consideration of the best available, most appropriate evidence in the care of each patient, a practice known as Evidence-based Medicine (EBM). EBM is dependent upon the wide availability and coverage of accurate, objective syntheses called evidence reports (also called systematic reviews). These are(More)
BACKGROUND Clinical studies of antipsychotic medication are a primary source of data on the nature of, and relative liability for, adverse effects, relevant to prescribing decisions in clinical practice. AIMS To identify how safety and tolerability data were collected and reported in recent clinical studies of antipsychotics. METHOD A survey was(More)
BACKGROUND Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ. Systematic reviews show that all relevant studies are small and none are likely to have adequate power to show true differences between treatments. Worldwide, current(More)