Clive E. Adams

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BACKGROUND Much biomedical research is now undertaken in China. METHODS Five large biomedical databases originating from China (CBM, CMCC, CNKI, VIP and WANFANG) are described and their utility and accessibility investigated. RESULTS These databases index 2500 journals largely not familiar to MEDLINE users. Free access, search features, record(More)
In the pragmatic-explanatory continuum, a randomized controlled trial (RCT) can at one extreme investigate whether a treatment could work in ideal circumstances (explanatory), or at the other extreme, whether it would work in everyday practice (pragmatic). How explanatory or pragmatic a study is can have implications for clinicians, policy makers, patients,(More)
BACKGROUND The aim was to reduce non-attendance for first-time consultations at psychiatric out-patient clinics. METHOD The study was a pragmatic randomized controlled trial; the setting was seven inner-city UK out-patient clinics in Leeds. The participants were 764 subjects of working age with an appointment to attend a psychiatric out-patient clinic for(More)
BACKGROUND Agitated or violent behaviour constitutes 10% of all emergency psychiatric treatment. Some guidelines do not recommend the use of chlorpromazine for rapid tranquillisation but it is still often used for this purpose. OBJECTIVES To examine the effects of oral or intramuscular chlorpromazine for psychosis induced agitation or aggression. SEARCH(More)
The Schizophrenia Patient Outcomes Research Team and others have previously included family psychoeducation and family support in best practices guidelines and treatment recommendations for persons with schizophrenia. In this article we review in detail 15 new studies on family interventions to consider issues around the implementation of family(More)
BACKGROUND Chlorpromazine, formulated in the 1950s, remains a benchmark treatment for people with schizophrenia. OBJECTIVES To review the effects of chlorpromazine compared with placebo, for the treatment of schizophrenia. SEARCH METHODS We searched the Cochrane Schizophrenia Group's Trials Register (15 May 2012). We also searched references of all(More)
Clive E. Adams, Evandro S. F. Coutinho, John Davis, Lorna Duggan, Stefan Leucht, Chunbo Li, and Prathap Tharyan Division of Psychiatry, University of Nottingham, UK; Department of Epidemiology and Quantitative Methods, ENSP-FIOCRUZ, Brazil; Psychiatric Institute, University of Illinois at Chicago; St Andrew’s Hospital, UK; Klinik für Psychiatrie und(More)
Valid reviews of the effects of mental health care depend on identifying as high a proportion as possible of relevant randomized controlled trials (RCTs). To investigate the sensitivity and precision both of MEDLINE and of hand-searching for RCTs in mental health, 12 journals specializing in mental health and indexed by the National Library of Medicine(More)
BACKGROUND Clinical studies of antipsychotic medication are a primary source of data on the nature of, and relative liability for, adverse effects, relevant to prescribing decisions in clinical practice. AIMS To identify how safety and tolerability data were collected and reported in recent clinical studies of antipsychotics. METHOD A survey was(More)
BACKGROUND Despite much being written on the topic, there are few surveys investigating the prevalence of anticholinergic adverse effects of antipsychotic drugs. One study, however, used trial-derived data to calculate estimates. OBJECTIVES To investigate the prevalence/incidence rates of anticholinergic effects as viewed from within relevant randomized(More)