Clinton R Morgan

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1-beta-D-Arabinofuranosylcytosine (ara-C) was tested at a concentration of 10 micrograms/ml in the human tumor colony-forming assay against 55 human tumors of various histological types. Using the criterion for sensitivity of at least 70% inhibition of colony formation, 12 tumors (22%) were sensitive to ara-C. ara-C was most active against lung tumors (3 of(More)
An improved method for testing human tumors against chemotherapeutic agents was developed. Drug effects were quantitated in the thymidine incorporation assay (TIA) by measuring inhibition of deoxyribonucleic acid (DNA) synthesis by the proliferating cell population following exposure to anticancer drugs. Results were obtained within five days. A total of(More)
BACKGROUND Although genetic profiling of tumors is a potentially powerful tool to predict drug sensitivity and resistance, its routine use has been limited because clinicians are often unfamiliar with interpretation and incorporation of the information into practice. We established a Molecular Tumor Board (MTB) to interpret individual patients' tumor(More)
This study examined overexpression of the opioid growth factor receptor (OGFr) in pancreatic cancer cells and phenotypic changes in tumorigenicity. Tumors of MIA PaCa-2 cells transfected with OGFr cDNA (OGFr-1) had 3.3 times more OGFr than empty vector (EV) neoplasias, and 4.3 times more OGFr than tumors from wild-type (WT) mice. No differences in OGFr(More)
This study examined overexpression of the opioid growth factor receptor (OGFr) in squamous cell carcinoma of the head and neck and phenotypic repercussions on tumorigenicity. Tumors from 3 SCC-1 cell lines (OGFr-9, OGFr-18, OGFr-22) stably transfected with OGFr cDNA (OGFr-1) had 2.5- to 3.7-fold more OGFr than empty vector (EV) or wild-type (WT) neoplasias.(More)
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