Clifford John Holmes

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Renal Electrolyte Division,1 University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Albany College of Pharmacy,2 Albany, New York, USA; Hans Mak Institute,3 Naarden, The Netherlands; Sanjay Gandhi Postgraduate Institute of Medical Sciences,4 Lucknow, India; Renal Division,5 Baxter Healthcare Corporation, McGaw Park, Illinois, USA; Department(More)
Epithelial mesenchymal transition (EMT), a process involved in many growth and repair functions, has been identified in the peritoneal tissues of patients who undergo peritoneal dialysis. The sequence of changes in gene regulation and cellular events associated with EMT after TGF-beta1-induced peritoneal fibrosis is reported. Sprague-Dawley rats received an(More)
Department of Medicine,1 Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, Minnesota; Albany College of Pharmacy,2 Albany, New York, U.S.A.; Department of Peritoneal Dialysis,3 Academic Medical Center, Amsterdam, The Netherlands; Manchester Royal Infirmary,4 Manchester, United Kingdom; Vanderbilt University Medical(More)
Ram Gokal,, Steven Alexander,, Stephen Ash,, Tzen W. Chen,, Anders Danielson,, Cliff Holmes,, Preben Joffe,, Jack Moncrief,, Kirt Nichols,, Beth Piraino,, Barbara Prowant,, Alain Slingeneyer,, Bernd Stegmayr,, Zbylut Twardowski,, Stephen Vas Manchester Royal Infirmary,, Manchester, U.K.; Stanford University Medical Centre,, Stanford, HemoCleanse,, West(More)
The peritoneal catheter is the CAPD patient's lifeline. Advances in catheter knowledge have made it possible to access the peritoneal cavity safely and maintain access over an extended period of time. Infection at the exit site remains a major problem, a solution for which is being extensively researched. The successful outcome of a catheter in an(More)
BACKGROUND Vascular calcification is common among end-stage renal disease (ESRD) patients and a central characteristic of the atherosclerotic cardiovascular disease observed in dialysis patients. Fetuin-A, a circulating calcium-regulatory glycoprotein that inhibits vascular calcification, is associated with inflammation and outcome in dialysis patients. In(More)
To identify the relative importance of peritoneal fibrosis and angiogenesis in peritoneal membrane dysfunction, adenoviral mediated gene transfer of angiostatin, a recognized angiogenesis inhibitor, and decorin, a transforming growth factor-beta-inhibiting proteoglycan, were used in a daily infusion model of peritoneal dialysis. A peritoneal catheter and(More)
Peritoneal dialysis solutions containing icodextrin are ideal for providing sustained ultrafiltration during long dwells, and they have replaced high glucose for long dwells in some patients. The biocompatibility of these solutions, especially in regard to glucose degradation products, has not been studied in depth. The object of this study was to compare(More)
The recommendations provided in this document represent a distillation of various experiences, as well as data obtained from published studies in the setting of substantial changes in antibiotic sensitivity. It is hoped that this revised compilation will provide a basis upon which future developments and advances can be made in the therapeutic approach to(More)