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STUDY OBJECTIVE To compare the efficacy of a novel antidote, insulin, with standard treatments, glucagon and epinephrine, in a canine model of acute beta-blocker toxicity. METHODS Anesthetized dogs were fitted with instruments by means of thoracotomy and vascular cutdown for multiple cardiodynamic, hemodynamic, metabolic, and electrical measures. After(More)
STUDY DESIGN Lumbar vertebral segments from young and old male sand rats were assessed for quantitative determination of lumbar end plate bone mineral density. OBJECTIVES To determine whether bone mineral density increases in the lumbar end plate with age in the male sand rat and to investigate its relationship to disc degeneration. SUMMARY OF THE(More)
STUDY DESIGN Lower lumbar vertebral endplates from young and old sand rats were assessed in an Institutional Animal Care and Use Committee approved study for architectural endplate features using micro-computerized tomography (CT) 3-dimensional (3D) models and vascularization studies by an in vivo vascular tracer or immunocytochemical identification of(More)
STUDY DESIGN Lumbar vertebral segments from a large cross-sectional population of male and female sand rats were assessed for quantitative determination of lumbar endplate bone mineral density (BMD) and radiologic features. OBJECTIVE To determine radiologic and BMD characteristics in the lumbar spines of males and females ranging in age from 1.5 to 46.0(More)
Animal studies and human case reports show promise in using lipid rescue to treat refractory calcium channel antagonist toxicity. However, the majority of research and clinical experience has focused on non-dihydropyridine agents. Thus, we sought to investigate the value of lipid emulsion (ILE) therapy for dihydropyridine-induced shock. This IACUC-approved(More)
Cognitive impairments play a large role in the lives of surviviors of mild traumatic brain injuries who are unable to return to their prior level of independence in their homes. Computational support has the potential to enable these individuals to regain control over some aspects of their lives. Our research aims to carefully seek out issues that might be(More)
PURPOSE The utility of in vivo confocal microscopy (IVCM) in the investigation of palpebral conjunctival and corneal inflammation in patients with meibomian gland dysfunction (MGD)-associated refractory dry eye symptoms following gland expression, despite objective clinical improvement. METHODS A retrospective, observational pilot study was conducted(More)
BACKGROUND CONTEXT The relationship between disc degeneration and end plate sclerosis is poorly understood. The sand rat is an excellent, economical small-animal model in which disc degeneration is age related, spontaneous, reliable, and well characterized. This model is used here to evaluate disc degeneration, disc cell viability, and vertebral end plate(More)