Cliff R. Wong

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Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided only modest survival benefits. This suboptimal outcome is likely due to physiological barriers that hinder delivery of the nanotherapeutics(More)
Local drug delivery into cartilage remains a challenge due to its dense extracellular matrix of negatively charged proteoglycans enmeshed within a collagen fibril network. The high negative fixed charge density of cartilage offers the unique opportunity to utilize electrostatic interactions to augment transport, binding and retention of drug carriers. With(More)
The LLNL Plutonium Facility contains significant quantities of fissile materials and thus must be able to provide dose estimates to effected individuals in the unlikely case of a nuclear criticality accident to meet the regulations set forth in the Code of Federal regulations, 10CFR835.1304, Nuclear Accident Dosimetry. In order to do this, the LLNL personal(More)
High particle uniformity, high photoluminescence quantum yields, narrow and symmetric emission spectral lineshapes and minimal single-dot emission intermittency (known as blinking) have been recognized as universal requirements for the successful use of colloidal quantum dots in nearly all optical applications. However, synthesizing samples that(More)
**This research was supported by the U.S. National Cancer Institute grants R01-CA126642 (R.K.J, D.F.,M.G.B, and D.G.N), R01CA085140, R01-CA115767 (R.K.J), P01-CA080124 (R.K.J and D.F), R01-CA096915 (D.F); by the MIT-Harvard NIH Center for Cancer Nanotechnology Excellence (1U54-CA119349) (M.G.B.); by the MIT DCIF (CHE-980806, DBI-9729592); by the ISN(More)
We present a new class of polymeric ligands for quantum dot (QD) water solubilization to yield biocompatible and derivatizable QDs with compact size (approximately 10-12 nm diameter), high quantum yields (>50%), excellent stability across a large pH range (pH 5-10.5), and low nonspecific binding. To address the fundamental problem of thiol instability in(More)
The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection probe delivery, have less adverse effects than conventional chemotherapy, and thus result in improved detection and treatment of tumors.(More)
Nanocrystal (NC) films have been proposed as an alternative to bulk semiconductors for electronic applications such as solar cells and photodetectors. One outstanding challenge in NC electronics is to robustly control the carrier type to create stable p-n homojunction-based devices. We demonstrate that the postsynthetic addition of Cd to InAs nanocrystals(More)
Assembly of functional nanocomponents offers promising applications in drug delivery to solid tumors and bottom-up synthesis and integration of nanodevices. This thesis presents a novel multistage nanoparticle delivery system consisting of an assembly of nanoparticles that can change its size to facilitate transport into solid tumors. Current FDA-approved(More)