Clementina H Castro

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BACKGROUND Frequent recurrent mutations in the breast and ovarian cancer susceptibility (BRCA) genes BRCA1 and BRCA2 among Hispanics, including a large rearrangement Mexican founder mutation (BRCA1 exon 9-12 deletion [ex9-12del]), suggest that an ancestry-informed BRCA-testing strategy could reduce disparities and promote cancer prevention by enabling(More)
BACKGROUND AND AIMS Fluoropyrimidine-based chemotherapy is the most common treatment for unresectable metastatic colorectal cancer (m-CRC). Therapy with 5-FU/folinic acid (FA) continues to be a standard treatment in developing countries. Pharmacogenomics allows the tailoring of cancer therapy to the patient. The polymorphism 677C>T of the(More)
In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns and covalent histone marks has been associated with cancer development. Until recently, microRNA (miRNA) gene silencing was not well understood. In particular, miR-125b1 has been suggested to be an miRNA with(More)
Satellite sequences are an important part of the pericentromeric regions in mammalian genomes; they play a relevant role in chromosome stability and DNA hypomethylation of these sequences has been reported in ICF syndrome and in some cancers that are closely associated with chromosomal abnormalities. Epigenetic modifications of satellite sequences and their(More)
BACKGROUND Mitotic arrest deficient 1 (MAD1), a protein of the mitotic spindle assembly checkpoint (SAC), recognizes MAD2 through two leucine zippers, transporting and activating MAD2, which promotes a metaphase arrest signal. A single nucleotide polymorphism of MAD1 was found to affect the SAC function that could be involved in a poor response to(More)
Heterochromatin protein 1 (HP1) is important in the establishment, propagation, and maintenance of constitutive heterochromatin, especially at the pericentromeric region. HP1 might participate in recruiting and directing Mis12 to the centromere during interphase, and HP1 disruption or abrogation might lead to the loss of Mis12 incorporation into the(More)
Background Chromosomal instability, aneuploidy in particular, plays an important role in the initiation, progression and aggressiveness of cancer cells. However, the mechanisms implicated in the formation of aneuploid cells are still not fully understood. DNA methylation is critical for condensation of chromatin and for determination of patterns of genetic(More)
Background CCCTC binding factor, also known as CTCF, has been described as a gene transcription promoting factor. On a genome–scale this protein is able to mediate long-range chromatin interactions enabling the regulation of the expression of domain genes. On a gene-scale CTCF is associated with an insulation function that counter propagation of methylation(More)
Background In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns and covalent histone marks has been associated with cancer development. In non-neoplastic cells the multifunctional CCCTC-binding factor (CTCF) can serve as a barrier against the spread of DNA(More)
Background Chromosomal segregation in eukaryotic cells is controlled by a group of proteins that constitute the mitotic spindle checkpoint (MSC). Any alteration in this checkpoint causes chromosomal instability, mainly aneuploidy. MAD1 is one of the MSC proteins, which has structural and regulatory functions that influence the cell cycle progress. MAD1(More)