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Conformational Changes in the Lower Palm Domain of ASIC1a Contribute to Desensitization and RFamide Modulation
- E. Frey, Ryan E. Pavlovicz, Clem John Wegman, C. Li, C. Askwith
- Biology, Medicine
- PloS one
- 14 August 2013
Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel that contributes to fear and pain as well as neuronal damage following persistent cerebral acidosis. Neuropeptides can affect… Expand