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BACKGROUND Lactation increases energy demands four- to five-fold, leading to a two- to three-fold increase in food consumption, requiring a proportional adjustment in the ability of the lactating dam to absorb nutrients and to synthesize critical biomolecules, such as cholesterol, to meet the dietary needs of both the offspring and the dam. The size and(More)
De novo synthesis of the steroidogenic acute regulatory protein (StAR) in response to trophic hormonal stimulation of steroidogenic cells is required for the delivery of cholesterol from the mitochondrial outer membrane to the mitochondrial inner membrane and the cytochrome P450 side-chain cleavage enzyme. StAR expression is transcriptionally regulated by(More)
Background Lactation requires increased nutrient uptake, as the mother must provide enough nutrition for her offspring while still meeting her own nutritional needs. The lactat-ing dam increases her food intake twofold to adjust for a threefold to four-fold increase in energy demands. We have used the Affymetrix Rat Exon 1.0 ST microarray in order to map(More)
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