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Survivors of meningitis often complain about neurological and neuropsychological consequences. In this study, the extent of these sequelae was quantified and correlated to MRI findings. Neurological, neuropsychological and neuroradiological examinations were performed with adult patients younger than 70 years, 1-12 years after recovery from bacterial(More)
Inflexibility of mental planning processes has repeatedly been discussed to represent a specific disorder resulting from human frontal lobe lesions. Patient groups suffering from acute or chronic unilateral frontal (medial, lateral) or retrorolandic (temporal, parietal) lesions and nonbrain-damaged controls were requested to mirror and to reverse mentally a(More)
A series of computerized mazes were masked during presentation allowing only partial view of their structure. Patients suffering from acute or chronic unilateral frontal (medial, lateral) or retrorolandic (temporal, parietal) lesions and non-brain-damaged controls were required to pass through the mazes repeatedly, until they solved them without reaching a(More)
BACKGROUND AND PURPOSE This study is aimed at the pathoanatomic correlates of depression in the postacute stage of patients with stroke. METHODS Of a consecutive series of 104 stroke patients, a subgroup of 47 patients with single demarcated unilateral lesions was selected. Clinical examination, neuroradiological CT scan examination, and psychiatric(More)
The present study aimed at the predictive value of early release patterns of protein S-100B and neuron specific enolase (NSE) in patients with traumatic brain injury. We investigated 69 patients who were admitted to the Department of Neurosurgery following traumatic brain injury. Both NSE and S-100B serum concentrations during the first three days after(More)
This study aimed at an analysis of glial fibrillary acidic protein (GFAP) in acute ischemic stroke, its association with the neurovascular status and its potential value as monitoring parameter. In 53 consecutive patients, serial venous blood samples were taken on admission, 6, 12, 18, 24, 48, 72, 96, and 120 h after stroke onset. The neurovascular status(More)
OBJECTIVES Analyses of neuron-specific enolase (NSE) and tau protein in patients with hyperacute ischemic stroke, their association with infarct volume, severity of the neurological deficit, the neurovascular status and functional outcome. PATIENTS AND METHODS In 66 consecutive patients, serial venous blood samples were taken at 3, 6, 12, 18, 24, 48, 72,(More)
Twelve patients with circumscribed chronic neocerebellar lesions but without CT-evidence of forebrain damage (other than the effects of shunting) were investigated for deficits of cognitive functions. Two different mechanisms were considered as possible causes of cognitive impairment: (1) Damage to the dentato-thalamo-cortical projection leading to(More)
BACKGROUND AND PURPOSE We sought to evaluate the diagnostic value of echo-enhanced transcranial color-coded duplex sonography (TCCD) and the clinical relevance of vascular pathology assessed by sonography for early clinical outcome in acute ischemic stroke. METHODS We present 23 consecutive patients with an anterior circulation stroke in whom clinical(More)
PURPOSE The present study aimed to measure the internal consistency, inter-rater-reliability and validity of the World Health Organisation Disability Assessment Schedule II (WHODAS II) for its application to stroke patients and their closest others. METHOD Patients were assessed 6 months and 1 year after stroke with the self- and proxy-rating versions of(More)