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The objective of the present study was to investigate the predictive value of islet cell antibodies (ICA) and insulin autoantibodies (IAA) for development of diabetes in women with previous gestational diabetes (GDM). Two hundred and forty-one previous diet-treated GDM patients and 57 women without previous GDM were examined 2-11 years after the index(More)
Glucose and insulin concentrations during basal fasting conditions and after an oral challenge with glucose have been studied during early, mid and late pregnancy and also after delivery in a group of 9 normal women. No significant changes in the fasting serum glucose concentration was observed during pregnancy. In contrast the fasting serum insulin(More)
Twenty-one patients with insulin-dependent diabetes mellitus (IDDM) participated in a 20-week randomized cross-over comparison of continuous subcutaneous insulin infusion (CSII) with intensified conventional treatment (ICT) using the NovoPen. The Medix or the Auto-Syringe pumps were used for CSII and, during ICT with NovoPen, conventional plastic syringes(More)
Glucose tolerance deteriorates in human pregnancy, but approximately 97-98% of all pregnant women retain a normal glucose tolerance, and only 2-3% develop gestational diabetes mellitus (GDM). Both nondiabetic pregnant women and women with GDM exhibit much higher insulin responses to oral or intravenous administration of glucose or amino acids than found in(More)
OBJECTIVES The purpose of this study was to determine the incidence of diabetes in women with previous dietary-treated gestational diabetes mellitus and to identify predictive factors for development of diabetes. STUDY DESIGN Two to 11 years post partum, glucose tolerance was investigated in 241 women with previous dietary-treated gestational diabetes(More)
OBJECTIVE To ascertain whether the decreased glucose tolerance and insulin resistance found in normal and gestational diabetic pregnancy might be associated with changes in insulin receptor function. METHODS Eight nonpregnant healthy women (nonpregnant controls), eight healthy pregnant women (pregnant controls), and eight women with gestational diabetes(More)
A patient with organic hypoglycemia but with normal pancreatic arteriography was investigated with pancreatic vein catheterization for insulin immunoassay. Very high insulin concentrations (1, 130 micronU/ml) were found in a vein draining part of the pancreatic tail. Even though no tumor was found at operation, distal hemipancreatectomy was performed(More)
The outcome of 223 pregnancies in Type 1 (insulin-dependent) diabetic women managed from 1981 to 1985 in the Centre for Pregnant Diabetics in Copenhagen is presented. There were 17 spontaneous and 9 induced abortions. The latter were all done on medical indications. Among the 201 infants weighing 1000 g or more (including 4 pairs of twins), three died(More)
Severe congenital malformations occur more often in infants of diabetic mothers than in infants of non-diabetic mothers. Fetuses exhibiting early fetal growth delay are in increased risk to be malformed and the early fetal growth rate seems to be related to the degree of metabolic control around the time of conception and in the early pregnancy. Nine(More)