Claus Grunwald

Learn More
Atlantic tomcod (Microgadus tomcod) from the cancer-prone Hudson River population exhibit a genetic polymorphism in the cytochrome P4501A (CYP1A) gene which is evidenced in Northern blot analyses by a truncated transcript and in Southern blot analyses by a deletion in the variant allele. To initially evaluate the functional significance of this(More)
The existence of steroid glycosides has been known for many years and, more recently, their derivatives have been described. Steroid glycosides have been isolated from a number of organisms, however, the largest number of these compounds are found in plants. As to glycoside biosynthesis, the sterols are the most extensively studied steroid group. Of the(More)
Shortnose sturgeon is an anadromous North American acipenserid that since 1973 has been designated as federally endangered in US waters. Historically, shortnose sturgeon occurred in as many as 19 rivers from the St. John River, NB, to the St. Johns River, FL, and these populations ranged in census size from 10(1) to 10(4), but little is known of their(More)
We determined levels of hepatic cytochrome P4501A (CYP1A) mRNA, hepatic DNA adducts, and fluorescent aromatic compounds (FACs) in bile, a measure of exposure to polyaromatic hydrocarbons, in Atlantic tomcod from six river systems ranging from highly polluted to relatively pristine on the northeast North American coast (the Hudson River, New York; the St.(More)
Microsatellite DNA and mitochondrial DNA control-region sequence analyses were used to determine the population and distinct population segment (DPS) origin of 173 Atlantic sturgeon Acipenser oxyrinchus oxyrinchus encountered from the Gulf of Maine to Cape Hatteras, North Carolina, in NOAA's Northeast Fisheries Observer Program. It was found that the Hudson(More)
CYP1A gene expression has been implicated in the processing of environmental procarcinogens and levels of variation in CYP1A mRNA expression are high in both environmentally exposed and chemically treated Atlantic tomcod. The objective of this study was to evaluate the effects of physical and biological parameters such as temperature, sex, and reproductive(More)
  • 1