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Digital stethoscopes offer new opportunities for computerized analysis of heart sounds. Segmentation of heart sound recordings into periods related to the first and second heart sound (S1 and S2) is fundamental in the analysis process. However, segmentation of heart sounds recorded with handheld stethoscopes in clinical environments is often complicated by(More)
The long QT syndrome (LQTS) is a genetic disorder, typically characterized by a prolonged QT interval in the ECG due to abnormal cardiac repolarization. LQTS may lead to syncopal episodes and sudden cardiac death. Various parameters based on T-wave morphology, as well as the QT interval itself have been shown to be useful discriminators, but no single ECG(More)
INTRODUCTION The Tpeak-Tend interval (TpTe) has been linked to increased arrhythmic risk. TpTe was investigated before and after primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI). METHOD Patients with first-time STEMI treated with pPCI were included (n = 101; mean age 62 years; range(More)
BACKGROUND Prolongation of the PR interval has been associated with an increased risk of incident atrial fibrillation (AF). OBJECTIVE To determine if there was a nonlinear relation between PR interval duration and the risk of AF. METHODS We included 288,181 individuals, corresponding to one third of the population in the greater region of Copenhagen.(More)
T-wave morphology descriptors are sensitive to drug-induced changes and may be a useful addition to the QT interval in cardiac safety trials. Intrasubject heart rate dependence of T-wave morphology was investigated in a sample of 39 healthy individuals. Ten-second electrocardiograms were obtained from daytime Holter recordings. Duration parameters (QT,(More)
INTRODUCTION Reference values for T-wave morphology analysis and evaluation of the relationship with age, sex, and heart rate are lacking in the literature. In this study, we characterized T-wave morphology in a large sample of healthy individuals. METHOD A total of 1081 healthy subjects (83% men; range, 17-81 years) were included. T-wave morphology(More)
Digital stethoscopes offer new opportunities for computerized analysis of heart sounds. Segmentation of hearts sounds is a fundamental step in the analyzing process. However segmentation of heart sounds recorded with handheld stethoscopes in clinical environments is often complicated by recording and background noise. A Duration-dependent Hidden Markov(More)
BACKGROUND We sought to perform a study assessing the association between electrocardiographic ST-segment deviations and cardiovascular death (CVD), in relation to sex and age (≥ and <65 years), in a large primary care population without overt ischemic heart disease. METHODS AND RESULTS Using computerized analysis of ECGs from 285 194 persons, we(More)
OBJECTIVE To determine how often cardiac resynchronization therapy (CRT) pacing systems generate visible pace spikes in the electrocardiogram (ECG). METHODS In 46 patients treated with CRT pacing systems, we recorded ECGs during intrinsic rhythm, atrial pacing and ventricular pacing. ECGs were analysed for atrial and ventricular pace spikes by two(More)
BACKGROUND Mutations in CAV3, coding for caveolin-3, the major constituent scaffolding protein of cardiac caveolae, have been associated with skeletal muscle disease, cardiomyopathy, and most recently long-QT syndrome (LQTS) and sudden infant death syndrome. We examined the occurrence of CAV3 mutations in a large cohort of patients with LQTS. METHODS AND(More)