Claudio M. D'Urso

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The melanoma cell line FO-1 does not express HLA class I antigens and does not acquire them on the cell surface after incubation with IFN-y. Immunochemical studies showed that FO-1 cells synthesize HLA class I heavy chain, but do not synthesize t#2-microglobulin (02-it). The latter abnormality is associated with lack of 82-mRNA which remains undetectable in(More)
The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated. In this experimental model, C57BL/6 mice received 30 mg/kg LPS (E. cell 055:B5) injected intraperitoneally, while L-carnitine and its(More)
The potential role of intercellular adhesion molecule 1 (ICAM-1) in the biology of human melanoma cells has stimulated interest in the characterization of its modulation. The present study has shown that the differentiating agent retinole acid (RA) up-regulates ICAM-1 expres sion by melanoma cells in a dose-and time-dependent fashion. The enhancement of(More)
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