Claudia Zucchi

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Voltage-dependent calcium channels are located in the plasma membrane and form a highly selective conduit by which Ca2+ ions enter all excitable cells and some nonexcitable cells. Extensive characterization studies have revealed the existence of one low (T) and five high-voltage-activated calcium channel types (L, N, P, Q, and R). The high voltage-activated(More)
Enantiomeric excesses obtained in absolute enantioselective synthesis by chiral autocatalysis (Soai-reaction) were statistically analyzed. Two sets of parallel experiments, which were performed under chemically different conditions, are available. One group contains 37, while the other contains 84 preparative results. The former group shows some interesting(More)
Natural-abundance isotopic substitution in isotopically prochiral groups of otherwise achiral molecules can provide stochastically formed enantiomeric excesses which exceed the sensitivity threshold of sensitive asymmetric autocatalytic (Soai-type) reactions. This kind of induction of chirality should be taken into consideration in in vitro model(More)
A carbohydrate-derivative alkylcobalt carbonyl,([(1,2:5,6-di-O,O-isopropylidene-alpha-D-glucofuranos-3-yl)oxycarbonyl]methyl)cobalt tricarbonyl triphenylphosphene(3) was prepared and characterized by IR, NMR, and CD spectra, as well as by X-ray diffraction. The supramolecular chemistry in the crystalline P2(1)2(1)2(1) (chiral) phase and in solution was(More)
Chiral conformations of flexible molecules may develop in a concerted manner if the molecule is crowded enough to assure sufficient level of through-the-space contacts. Higher number (> 4) of groups connected to the same atom, as in many coordination compounds, can be advantageous in this respect. The case study of R,S-[(sec-butoxycarbonyl)methyl]cobalt(More)
The emerging discipline of astrobiology could gain valuable support from research dealing with the problems of biological chirality. The most profitable fields of common interest are: (a) living organisms under extraterrestrial conditions, (b) extraterrestrial signatures of life and (c) origin(s) of biological chirality. These areas of complementary and(More)