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Potential clinical implications of BRAF mutations in histiocytic proliferations
For a growing number of tumors the BRAF V600E mutation carries therapeutic relevance. In histiocytic proliferations the distribution of BRAF mutations and their relevance has not been clarified. Here… Expand
GOT1/AST1 expression status as a prognostic biomarker in pancreatic ductal adenocarcinoma
Prognostication in pancreatic ductal adenocarcinoma (PDAC) remains a challenge. Recently, a link between mutated KRAS and glutamic-oxaloacetic transaminase (GOT1/AST1) has been described as part of… Expand
Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011
BackgroundOver the past two decades, there has been a rising trend in malignant melanoma incidence worldwide. In 2008, Germany introduced a nationwide skin cancer screening program starting at age… Expand
Suppressor of cytokine signaling 1 gene mutation status as a prognostic biomarker in classical Hodgkin lymphoma
Suppressor of cytokine signaling 1 (SOCS1) mutations are among the most frequent somatic mutations in classical Hodgkin lymphoma (cHL), yet their prognostic relevance in cHL is unexplored. Here, we… Expand
Absence of FLICE-Inhibitory Protein Is a Novel Independent Prognostic Marker for Very Short Survival in Pancreatic Ductal Adenocarcinoma
Objectives Evading apoptosis is a hallmark of pancreatic cancer. In pancreatic cancer models, chemotherapy down-regulates the antiapoptotic protein cellular FLICE inhibitory protein (c-FLIP), which… Expand
Searches for R-parity-violating supersymmetry in pp collisions at ffiffi s p = 8 TeV in final states with 0 – 4 leptons
AST/GOT1 expression status in primary resection specimen as a prognostic biomarker in human pancreatic ductal adenocarcinoma (PDAC).
e15245 Background: A novel metabolic link in PDAC has recently been established whereby the mutated KRAS molecule acts as a modulator of the cancer cell’s redox maintenance system via an increase in… Expand
LHCSki 2016 - A First Discussion of 13 TeV Results
These are the proceedings of the LHCSki 2016 workshop "A First Discussion of 13 TeV Results" that has been held at the Obergurgl Universit\"atszentrum, Tirol, Austria, April 10 - 15, 2016. In this… Expand