Claudia Sofie Schmitz

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Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies to certain cellular macromolecules, such as the small nuclear ribonucleoprotein particles (snRNPs), which had been considered to be passive targets of the autoimmune response. SLE is also characterized by the increased expression of type I(More)
BACKGROUND AND OBJECTIVE To investigate the interactions of postoperative pain and endocrine stress response, three groups of 21 patients each with total knee arthroplasty were compared in a randomized, prospective design. For postoperative pain management, a three-in-one block, an epidural catheter analgesia or an intravenous patient-controlled analgesia(More)
1 Coley Pharmaceutical GmbH, 40764 Langenfeld, Germany 2 Institute for Medical Microbiology, Hygiene and Immunology, D-81675 Munich, Germany 3 Department of Host Defense, Research Institute for Microbial Diseases, Suita, Osaka 565-0871, Japan 4 ERATO, Japan Science and Technology Corporation, Osaka 565-0047, Japan 5 Rheumatology and Clinical Immunology,(More)
Adverse effects of resuscitation due to closed-chest cardiac massage are common, and the incidence is increased when an incorrect technique is used. Nevertheless, thrombolytic therapy of a myocardial infarction can become necessary even after cardiopulmonary resuscitation (CPR). In these patients, the risk of thrombolytic therapy-induced bleeding is(More)
This prospective, randomised study compared total intravenous anaesthesia (TIVA) and inhalation anaesthesia with respect to endocrine stress response, haemodynamic reactions, and recovery. METHODS. The investigation included two groups of 20 ASA I-II patients 18-60 years of age scheduled for orthopaedic surgery. For premedication of both groups, 0.1 mg/kg(More)
The toll-like receptors (TLRs) 7, 8, and 9 stimulate innate immune responses upon recognizing pathogen nucleic acids. Certain GU- or AU-rich RNA sequences were described to differentiate between human TLR7- and TLR8-mediated immune effects. Those single-stranded RNA molecules require endosomal delivery for stabilization against ribonucleases. We have(More)
OBJECTIVE The study was undertaken to investigate the influence of two different regimens of analgosedation on control and quality of sedation, stress response and haemodynamic parameters. METHODS After ethical approval, 30 surgical intensive care patients were investigated in an open, controlled design. Patients with initial cardiocirculatory stability(More)
In this prospective, randomized study, two regimens of total intravenous anaesthesia (TIVA), with propofol and S(+)-ketamine (S-ketamine) and with propofol and alfentanil, were compared with reference to endocrine stress response, circulatory effects and recovery. METHODS. The investigation was conducted in two groups of 20 ASA I-III patients over 60 years(More)
Staphylococcus aureus surgical site infection. Infect Control Hosp Epidemiol 2008; 29:890-893. 10. Manian FA, Meyer PL, Setzer J, Senkel D. Surgical site infections associated with methicillin-resistant Staphylococcus aureus: do postoperative factors play a role? Clin Infect Dis 2003; 36:864-868. 11. Finkelstein R, Rabino G, Mashiah T, et al. Vancomycin(More)
Bei zwei Patienten im Alter von 44 bzw. 52 Jahren mit frischem Myokardinfarkt kam es nach außerklinischer kardiopulmonaler Reanimation (CPR) und nachfolgender klinischer systemischer Thrombolysetherapie zu einer bedrohlichen Verschlechterung der Kreislaufsituation. Bei unauffälligem radiologischen Thoraxbefund war sonographisch in beiden Fällen freie(More)