Claudia Prajescu

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Despite much progress over the past decade, current single nucleotide polymorphism (SNP) genotyping technologies still offer an insufficient degree of multiplexing when required to handle user selected sets of SNPs. In this paper we propose a new genotyping assay architecture combining multiplexed solution-phase single-base extension (SBE) reactions with(More)
In this paper we address two optimization problems arising in the design of genomic assays based on universal tag arrays. First, we address the universal array tag set design problem. For this problem, we extend previous formulations to incorporate antitag-to-antitag hybridiza-tion constraints in addition to constraints on antitag-to-tag hybridization(More)
1 Introduction High throughput genomic technologies have revolutionized biomedical sciences, and progress in this area continues at an accelerated pace in response to the increasingly varied needs of biomedical research. Among emerging technologies, one of the most promising is the use of universal tag arrays (UTA) [4]. A universal tag array consists of a(More)
2005 ii Acknowledgements I most especially thank my advisor, Ion M˘ andoiu, without whom this work would not have been done. For giving me the opportunity to study here, for all his tireless help, for invaluable advice and suggestions, I am most grateful to him. I also want to express my gratitude to my former advisor at the A.I.Cuza University of Ia¸si,(More)
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