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The reaction of proteins with reducing sugars leads to the formation of 'advanced glycation endproducts' (AGEs). They accumulate in Alzheimer's disease brain in the vicinity of beta-amyloid plaques.(More)
Advanced glycation endproducts (AGEs) accumulate on long-lived proteins, including beta-amyloid plaques in Alzheimer's disease, and are suggested to contribute to neuronal dysfunction and cell death.(More)
β-amyloid peptide (Aβ) and “Advanced glycation endproducts” (AGEs) are components of the senile plaques in Alzheimer’s disease patients. It has been proposed that both AGEs and Aβ exert many of their(More)