Claudia Langebrake

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Multidrug resistance (MDR), a challenge in treating childhood acute myeloid leukemia (AML), is frequently associated with decreased drug accumulation caused by multidrug transporter MDR1.(More)
The fusion transcript AML1/ETO corresponding to translocation t(8;21)(q22;q22) can be found in approximately 7–12% of childhood de novo AML. Despite the favorable prognosis, some of these patients(More)
It has increasingly been acknowledged that only a few leukaemic cells possess the capability to renew themselves and that only these self-renewing leukaemic stem cells are able to initiate relapses.(More)