Claudia J Clayton

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The development of pituitary adenomas in female C57BL/6J mice was studied over the lifespan. Mammotrophs and somatotrophs, identified by immunocytochemical staining, appeared normal in 3-4 month old animals, with the exception of an occasional hypertrophic mammotroph and, in one gland, a nest of such cells. At 15 months, hypertrophic mammotrophs,(More)
The principle of rate-dependency has been proposed to explain the therapeutic effects of stimulant drugs in hyperactive children (HAC). This paper is a critical discussion of the salience of rate-dependency to childhood hyperactivity, on mathematical, theoretical and clinical levels. The results of a stimulant drug trial in 55 HAC are presented; the data(More)
The violent and peaceful behaviors of 115 children who had or had not witnessed domestic violence were measured in five types of simulated conflict. Witnesses did not differ from nonwitnesses in conflicts involving limited resources, jealousy over possessions, or intimidation; witnesses were significantly more violent in conflicts involving aggression and(More)
Evidence suggests that ethanol self-administration is directly related to central norepinephrine (NE) activity and inversely related to central serotonin (5-HT) activity. Normal male volunteers participated in a placebo controlled crossover design to assess the effects of 1-tyrosine (TY) and 1-tryptophan (TP) (precursors of catecholamines and 5-HT,(More)
Child witnesses' use of violent or peaceful strategies to resolve conflicts with peers were compared with strategies used by nonwitnesses. Stories depicting 5 types of peer conflicts were presented to each child, and the strategies used by the child to reach peaceful resolutions were scored. Findings include differences between witnesses and nonwitnesses,(More)
Thyrotropin-releasing hormone (TRH) has been shown to antagonize the depressant effects of ethanol in animals, but conflicting findings have been reported in humans. To test whether TRH counteracts any of a variety of ethanol-sensitive behavioral measures in normal human subjects and for an effect of ethanol on TRH-induced thyrotropin (TSH) and prolactin(More)
An antiserum which has previously been thought to be specific for LHRH-like immunoreactive material was shown to contain two populations of antibodies, one demonstrating anti-LHRH activity and the other anti-ACTH(1-24) activity. In rat and mouse, ACTH(1-24)-like immunoreactive substance is present in perikarya within the basal hypothalamus and in fibers in(More)
Immunocytochemical staining of luteinizing hormone-releasing hormone (LHRH), somatostatin, and neurophysin was compared in rat brains fixed with 1) formalin, 2) Bouin's solution, 3) freeze-dried (FD), or 4) freeze-dried + paraformaldehyde vapor perfused (FDV). The distribution of LHRH fibers was similar in all preparations; however, beads of granular(More)
In this paper, we consider the following basic question. Let A be an L-structure and let ψ be an infinitary sentence in the language L ∪ {R}, where R is a new relation symbol. When is it the case that for every B ∼ = A, there is a relation R such that (B, R)ψ and R ≤ T D(B)? We succeed in giving necessary and sufficient conditions in the case where ψ is a "(More)
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