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OBJECTIVE To compare the performance characteristics of cell-bound complement (C4d) activation products (CBCAPS) on erythrocyte (EC4d) and B cells (BC4d) with antibodies to double-stranded DNA (anti-dsDNA) and complement C3 and C4 in systemic lupus erythematosus (SLE). METHODS The study enrolled 794 subjects consisting of 304 SLE and a control group(More)
Expression of the sigma(D)-dependent flagellin gene, hag, is repressed by the CodY protein in nutrient-rich environments. Analysis of a codY mutant bearing a hag-lacZ reporter suggests that the availability of amino acids in the environment is the specific signal that triggers this repression. Further, hag-lacZ expression appears to be sensitive to(More)
The interaction of guanine nucleotides with the chick cerebellar kainate binding protein (chKBP) was studied using binding assays, immunoblotting, and in vitro phosphorylation experiments. Guanosine 5'-triphosphate (GTP) was found to reduce [3H]kainic acid (KA) binding in a concentration-dependent manner. Similarly, an inhibition of [3H]GTP binding by KA(More)
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