Claudia Hoffmann

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A case of biopsy verified progressive multifocal leucoencephalopathy (PML) in an HIV patient is presented. Imaging and histological examination confirmed remarkable inflammatory activity accompanied by an unusually benign clinical course despite no clear evidence of immune reconstitution after the start of antiretroviral treatment. This case not only raises(More)
The innate immune system is of vital importance for protection against infectious pathogens. Inflammasome mediated caspase-1 activation and subsequent release of pro-inflammatory cytokines like IL-1beta and IL-18 is an important arm of the innate immune system. Salmonella enterica subspecies 1 serovar Typhimurium (S. Typhimurium, SL1344) is an(More)
Tumor progression is controlled by signals from cellular and extra-cellular microenvironment including stromal cells and the extracellular matrix. Consequently, three-dimensional in vitro tumor models are essential to study the interaction of tumor cells with their microenvironment appropriately in a biologically relevant manner. We have previously used(More)
Caspase-1 is an important converging point for danger signals initiating inflammation and defense. Recent work suggests that RhoGTPase activation and/or cyto-skeletal disturbance may represent a novel pathway eliciting caspase-1 responses that are subverted by several enteropathogenic bacteria. The enteropathogen Salmonella Typhimurium employs the type III(More)
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