Claudia Hoffmann

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The innate immune system is of vital importance for protection against infectious pathogens. Inflammasome mediated caspase-1 activation and subsequent release of pro-inflammatory cytokines like IL-1beta and IL-18 is an important arm of the innate immune system. Salmonella enterica subspecies 1 serovar Typhimurium (S. Typhimurium, SL1344) is an(More)
Tumor progression is controlled by signals from cellular and extra-cellular microenvironment including stromal cells and the extracellular matrix. Consequently, three-dimensional in vitro tumor models are essential to study the interaction of tumor cells with their microenvironment appropriately in a biologically relevant manner. We have previously used(More)
Caspase-1 is an important converging point for danger signals initiating inflammation and defense. Recent work suggests that RhoGTPase activation and/or cyto-skeletal disturbance may represent a novel pathway eliciting caspase-1 responses that are subverted by several enteropathogenic bacteria. The enteropathogen Salmonella Typhimurium employs the type III(More)
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