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Increased cell-to-cell variation in gene expression in ageing mouse heart

• Rumana Bahar, Claudia H. Hartmann, +8 authors Jan Vijg
• Nature
• 2006

The accumulation of somatic DNA damage has been implicated as a cause of ageing in metazoa. One possible mechanism by which increased DNA damage could lead to cellular degeneration and death is by… (More)

Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer.

• Julian A Schardt, Manfred Meyer, +7 authors Christoph A Klein
• Cancer cell
• 2005

Chromosomal instability in human breast cancer is known to take place before mammary neoplasias display morphological signs of invasion. We describe here the unexpected finding of a tumor cell… (More)

Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer.

• Nikolas H Stoecklein, Stefan Benedikt Hosch, +14 authors Christoph A Klein
• Cancer cell
• 2008

The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression. To address this problem, we studied the… (More)

Gene expression profiling of single cells on large-scale oligonucleotide arrays

• Claudia H. Hartmann, Christoph A. Klein
• Nucleic acids research
• 2006

Over the last decade, important insights into the regulation of cellular responses to various stimuli were gained by global gene expression analyses of cell populations. More recently, specific cell… (More)

Cloning, expression, purification, and characterization of the membrane protein UncI from Escherichia coli.

• Claudia H. Hartmann, Andreas H. Engel
• Protein expression and purification
• 2011

The Escherichia coli unc-operon encodes the genes for the subunits of the F0F1-ATP synthase and an integral membrane protein of unknown function called UncI. UncI influences the cell-growth and… (More)

Author Index Author Index for Volume 441 Increased Cell-to-cell Variation in Gene Expression in Ageing Mouse Heart (with

• Claudia H. Hartmann, Karl A. Rodriguez, +19 authors Hubert P J C de Leeuw

A distal enhancer and an ultraconserved exon are derived from a novel retroposon (Brar, G A. Rec8 phosphorylation and recombination promote the step-wise loss of cohesions in meiosis (

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