Claudia Gasch

Learn More
BACKGROUND Multiparametric magnetic resonance imaging (mpMRI) and MRI fusion targeted biopsy (FTB) detect significant prostate cancer (sPCa) more accurately than conventional biopsies alone. OBJECTIVE To evaluate the detection accuracy of mpMRI and FTB on radical prostatectomy (RP) specimen. DESIGN, SETTING AND PARTICIPANTS From a cohort of 755 men who(More)
Das Prostatakarzinom (PCa) ist die häufigste Krebserkrankung bei Männern in Industrieländern. Zu Verbesserung der PCa-Diagnostik wurde in den letzten Jahren 68Ga-PSMA-11 als neuer PET-Tracer (Positronen-Emissions-Tomographie) entwickelt. 68Ga-PSMA-11 bindet hochspezifisch an das prostataspezifische Membranantigen (PSMA), welches bei dem überwiegenden Teil(More)
INTRODUCTION Laparoscopic partial nephrectomy (LPN) remains challenging in endophytic and complex kidney tumors as the clear understanding of tumor location and spreading depends on a precise analysis of available imaging. The purpose of this study was to investigate navigated kidney surgery using intraoperative cone-beam computed tomography (CBCT) images(More)
Despite decades of research, ovarian cancer is still associated with unacceptably high mortality rates, which must be addressed by novel therapeutic approaches. One avenue through which this may be achieved is targeting of tumor-initiating ‘Cancer Stem Cells’ (CSCs). CSCs are sufficient to generate primary and recurrent disease through extensive rounds of(More)
Resistance to neoadjuvant chemoradiation therapy (CRT) remains a critical barrier to the effective treatment of esophageal adenocarcinoma (EAC). Cancer stem-like cells (CSCs) are a distinct subpopulation of cells implicated in the resistance of tumors to anti-cancer therapy. However, their role in the resistance of EAC to CRT is largely unknown. In this(More)
Beef cattle from 3 independent studies conducted in the Texas Panhandle (Exp. 1: n = 3,906 and Exp. 2: n = 4,000) and southern Idaho (Exp. 3; n = 542) were used to investigate the association of pro-melanin concentrating hormone (PMCH) genotype with beef carcass quality and yield attributes. Tissue samples were collected from each animal to determine which(More)
It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted efforts, CSC-targeting strategies have not been efficiently translated to the clinic. This is partly due to our incomplete understanding of the(More)
The objective of this study was to quantify the effects of zilpaterol hydrochloride (ZH) on feeding performance and fabrication yield of concentrate-finished cull cows. Three hundred twenty commercial cull cows (2 to 10 yr old) were obtained from ranches in Missouri and South Dakota and assigned to 1 of 2 treatments: 1) a control diet containing no ZH and(More)
Das Nierenzellkarzinom mit supradiaphragmalem Cavathrombus ist eine seltene Tumorentität. Die Operation mittels Nephrektomie und Thrombektomie gilt als Therapiestandard. Präoperativ ist mittels Magnetresonanztomographie und transösophagealer Echokardiographie das Ausmaß des Thrombus zu evaluieren. Die Operationsplanung und -durchführung sollte in(More)
OBJECTIVE This study is a prospective evaluation of a volume-based, computer-assisted method for transperineal optimized prostate (TOP) biopsy. The TOP algorithm automates core planning for systematic prostate biopsies using the 3-dimensional organ contour and an alterable volume for tumors to be excluded. SUBJECTS AND METHODS MRI-transrectal ultrasound(More)