Claudia E. Alvarez

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DGq is the alpha subunit of the heterotrimeric GTPase (G alpha), which couples rhodopsin to phospholipase C in Drosophila vision. We have uncovered three duplicated exons in dgq by scanning the GenBank data base for unrecognized coding sequences. These alternative exons encode sites involved in GTPase activity and G beta-binding, NorpA (phospholipase(More)
OBJECTIVES The goal of the present study was to determine the efficacy of combinatorial treatment using cisplatin and tumor necrosis factor-related apoptosis including ligand (TRAIL) to promote apoptosis in granulosa cell tumor (GCT) lines, in vitro. METHODS Two human GCT lines (COV434 and KGN) were treated with cisplatin or TRAIL, alone or in(More)
Human ovarian cancers of granulosa cell origin currently represent approximately 3 to 5% of diagnosed cancers involving the ovary. Nevertheless, there is little known regarding either the etiology or selective treatment of granulosa cell tumors (GCT) as compared to those originating from surface epithelial cells. The ability of TRAIL to target cancer cells(More)
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