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Formation and accumulation of fibrillar plaques and aggregates of beta-amyloid peptide (Abeta) in brain have been recognized as characteristics of Alzheimer's disease (AD). Oligomeric aggregates of Ass are considered critical intermediates leading to progressive neurodegeneration; however, molecular details of the oligomerization and aggregation pathway and(More)
Alzheimer's disease (AD) is the most prevalent form of age-related neurodementia. The accumulation of beta-amyloid polypeptide (Abeta) in brain is generally believed to be a key event in AD. The recent discovery of physiological beta-amyloid autoantibodies represents a promising perspective for treatment and early diagnosis of AD. The mechanisms by which(More)
my PhD work in his laboratory, for his guidance and kind advice throughout the years; Dr. Malte Drescher for helping me to understand the secrets of electron paramagnetic resonance and for writing the second review of this thesis; their hospitality and the experience gained in their laboratories; All members of the group for their help, advice and inspiring(More)
BACKGROUND Mucopolysaccharidosis IVA (MPS IVA; Morquio A disease) is an autosomal recessive disease caused and characterized by a decreased activity of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), resulting in accumulation of keratan sulfate and chondroitin-6-sulfate in tissues and secondary organ damage. Recently approved enzyme replacement therapy(More)
2009 For my wonderful parents Maria and Julio Almeida. " Do not follow where the path may lead. Go, instead, where there is no path and leave a trial. " Anonymous " Learn from yesterday, live for today, hope for tomorrow. The important thing is to not stop questioning. Curiosity has its own reason for existing. " Albert Einstein Slamnoiu and Reinhold Weber(More)
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