Claudette Arthur

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BACKGROUND Abdominal aortic aneurysms (AAAs) are characterized by histologic signs of chronic inflammation, destructive remodeling of extracellular matrix, and depletion of vascular smooth muscle cells. We investigated the process of extracellular matrix remodeling by performing a genetic association study with polymorphisms in the genes for matrix(More)
OBJECTIVE This study investigated a large number of families in which at least two individuals were diagnosed with abdominal aortic aneurysms to identify the relationship of the affected relatives to the proband. SUBJECTS AND METHODS Families for the study were recruited through various vascular surgery centers in the United States, Finland, Belgium,(More)
BACKGROUND Abdominal aortic aneurysm (AAA) is a relatively common disease, with 1% to 2% of the population harboring aneurysms. Genetic risk factors are likely to contribute to the development of AAAs, although no such risk factors have been identified. METHODS AND RESULTS We performed a whole-genome scan of AAA using affected-relative-pair (ARP) linkage(More)
BACKGROUND Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms. METHODS HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387(More)
BACKGROUND Abdominal aortic aneurysms (AAAs) are frequently familial. The aim of this study was to compare the prevalence of AAA among the siblings of AAA patients with that in the spouses' siblings. METHODS The siblings of 375 AAA patients and the siblings of the spouses of the AAA patients were included in this study and offered ultrasonography(More)
Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with human leukocyte antigen (HLA) polymorphisms (HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles) in 387 AAA cases(More)
Verloes, Claudette Arthur, Alan G. Lossing, Marjorie Burnett, Taijiro Sueda and Helena Sakalihasan, Gerard Pals, Raymond Limet, Gerald L. MacKean, Olivier Defawe, Alain Buxbaum, Doreen M. Dudek, Gerard Tromp, Toru Ogata, Magdalena Skunca, Natzi Hidenori Shibamura, Jane M. Olson, Clarissa van Vlijmen-van Keulen, Sarah G. Chromosome 19q13 History as(More)
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