Claude Touzet

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It has been proposed that visual recognition memory and certain attentional mechanisms are impaired early in Alzheimer disease (AD). Little is known about visuospatial recognition memory in AD. The crucial role of the hippocampus on spatial memory and its damage in AD suggest that visuospatial recognition memory may also be impaired early. The aim of the(More)
The aim of this study was to determine the neurobiological bases of behavioral deficits associated with cholinergic damage and the potential of long-term environmental enrichment as a therapeutic agent. Rats were submitted to intra-structures injection of 192 IgG-saporin and then behaviorally tested 1 month and 1 year post-lesion in a(More)
This paper is concerned with the improvement of reinforcement learning through the use of forbidden sequences of actions. A given reinforcement function can generate multiple effective behaviors. Each behavior is effective only considering the cumulative reward over time. It may not be the behavior expected by the designer. In this case, the usual solution(More)
An Adaptive Resonance Theory (ART) network was trained to identify unique orthographic word forms. Each word input to the model was represented as an unordered set of ordered letter pairs (open bigrams) that implement a flexible prelexical orthographic code. The network learned to map this prelexical orthographic code onto unique word representations(More)
To QUANTIFY human tumour-cell sensitivity to cytostatic agents, Salmon et al. (1978) described an in vitro cloning assay employing direct plating of tumour cells. Using this method, we studied 34 mam-mary epithelial tumours: cells were obtained from the primary tumour in 29 cases, and from secondary pleural effusions in 5 cases. The solid tumours were(More)
Despite the predation costs, sleep is ubiquitous in the animal realm. Humans spend a third of their life sleeping, and the quality of sleep has been related to co-morbidity, Alzheimer disease, etc. Excessive wakefulness induces rapid changes in cognitive performances, and it is claimed that one could die of sleep deprivation as quickly as by absence of(More)
Sleep is ubiquitous among the animal realm, and represents about 30% of our lives. Despite numerous efforts, the reason behind our need for sleep is still unknown. The Theory of neuronal Cognition (TnC) proposes that sleep is the period of time during which the local inhibitory synapses (in particular the cortical ones) are replenished. Indeed, as long as(More)
"Neurotrophic signaling molecules associated with cholinergic damage in young and aged rats-Environmental enrichment as potential therapeutic agent", Importance des facteurs attentionnels et mnésiques lors de l'accès aux sites Web. In A. Piolat (Ed.). Lire, écrire, communiquer et apprendre avec Internet, Marseille : Editions Solal.