Claude Petit

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OBJECTIVE Experience of pain in major depressive disorder (MDD) can complicate diagnosis and impair treatment outcomes. This study evaluated the efficacy and safety of duloxetine in the treatment of patients with moderate pain associated with depression. METHOD In this double-blind, placebo-controlled, 8-week study, conducted from May 2005 to May 2006,(More)
The impact of cell (mobile) phone use on driving performance has been widely questioned for 20 years. This paper reviews the literature to evaluate the extent to which phoning may impact behaviour with a risk to affect safety. After analysing epidemiological studies that give an overview of cell phone use, this paper examines the experimental results and(More)
OBJECTIVES This post hoc analysis compared how patients and physicians estimate disease severity and global improvement during 8 weeks of treatment for major depressive disorder (MDD) with associated nonspecific pain. In addition, predictors of pain and depression were identified. METHOD Data were derived from a double-blind, placebo-controlled,(More)
Polo-like kinase 1 (Plk1) is expressed during mitosis and overexpressed in multiple cancers, including non-Hodgkin lymphoma (NHL). This phase I study determined the maximum tolerated dose (MTD) of BI 2536, a Plk1 inhibitor, as a 1 h infusion once every 3 weeks in post-transplant relapsed (n = 17) and transplant-naive (n = 24) patients with(More)
OBJECTIVE This post hoc analysis assessed improvements in a broad range of psychopathological dimensions and in interference of pain with functioning as well as the time course of these improvements in patients with major depressive disorder (MDD) and pain treated with duloxetine versus placebo. RESEARCH DESIGN AND METHODS Data were derived from an(More)
Sharing attention between two tasks requiring the same mental resources is supposed to increase the resulting strain. Phoning while driving may elicit cognitive interference between driving operations and conversation and consequently, may affect driving efficiency. The road scene cues may thus be perceived late or even omitted, increasing the probability(More)
The first paper examined how the variables related to driving performance were impacted by the management of holding a phone conversation. However, the conditions under which this dual task is carried out are dependent upon a set of factors that may particularly influence the risk of crash. These conditions are defined by several independent variables,(More)
Pharmacoeconomic studies are performed in a higher frequency to assess the economic interest of new drugs. However, a standard methodology does not still completely exist. We present here the principles and results of a cost-effectiveness Bayesian analysis on data from 146 patients (interim analysis) collected during a clinical trial. This trial was(More)
This research describes a meta-model which can generate multiagents system (MAS) of strategic decision support. These MAS profit from new concepts of bargaining with learning to determine the cooperation between agents. They answer an insufficiency of the concept of bargaining in the game theory which is proved in this article. The original framework of the(More)
Physiological signals like Heart Rate, Respiration and Skin Resistance are relevant indicators to evaluate driver's mental state. Therefore, most methods based on physiological signals measurements have been improved on driving simulators or in experimental laboratories under carefully controlled conditions and rigorous protocols. To study driver's behavior(More)