Claude Laurent Benhamou

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UNLABELLED In an open-label extension study, BMD increased continuously with strontium ranelate over 10 years in osteoporotic women (P < 0.01). Vertebral and nonvertebral fracture incidence was lower between 5 and 10 years than in a matched placebo group over 5 years (P < 0.05). Strontium ranelate's antifracture efficacy appears to be maintained long term.(More)
The benefit of impact-loading activity for bone strength depends on whether the additional bone mineral content (BMC) accrued at loaded sites is due to an increased bone size, volumetric bone mineral density (vBMD) or both. Using magnetic resonance imaging (MRI) and dual energy X-ray absorptiometry (DXA), the aim of this study was to characterize the(More)
In this paper, we present a new method for modeling disordered porous media. Recent work has shown that the line skeleton is a powerful tool for 3D structure characterization. However, as it generates only 1D curves, the geometry of the material is sometimes excessively approximated. Our algorithm is an improved solution as it considers the local shape of(More)
It has been shown that the analysis of two dimensional (2D) bone X-ray images based on the fractional Brownian motion (fBm) model is a good indicator for quantifying alterations in the three dimensional (3D) bone micro-architecture. However, this 2D measurement is not a direct assessment of the 3D bone properties. In this paper, we first show that S(3D),(More)
This communication presents a new method to compute a precise shape-dependant skeleton and its application to porous media. The local geometry of the ob-ject's structure is taken into account in order to switch between curve and surface thinning criterions. The resulting skeleton combines 2D surfaces and 1D curves to represent respectively the plate-shaped(More)
In order to prevent bone fractures due to disease and ageing of the population, and to detect problems while still in their early stages, 3D bone micro architecture needs to be investigated and characterized. Here, we have developed various image processing and simulation techniques to investigate bone micro architecture and its mechanical stiffness. We(More)
The combination of skeletons and Finite Elements (FE) analysis has recently shown its great potential in disordered porous media characterization. A full protocol for creating simplified skeleton-based FE models of large-scale disordered porous media and evaluating their stiffness is presented in this paper. The method uses a sequence of image processing(More)
The clinical process used to screen osteoporosis is the Bone Mineral Density (BMD). Since this density measurement does not cover the entire diagnosis range, work is being carried out on the segmentation of the bone and other complex porous media to provide quantitative information about their microarchitecture. Two shape classification techniques have been(More)
The objective of this study was to explore Laws' masks as a new application of texture analysis to characterise bone micro-architecture and to check its dependence from the spatial resolution. The method is based on masks that aim to filter the images. From each mask, classical statistical parameters can be calculated. Our study was performed on 114 women(More)