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Biological substitutes for autologous bone flaps could be generated by combining flap pre-fabrication and bone tissue engineering concepts. Here, we investigated the pattern of neotissue formation within large pre-fabricated engineered bone flaps in rabbits. Bone marrow stromal cells from 12 New Zealand White rabbits were expanded and uniformly seeded in(More)
BACKGROUND Sarcoidosis is a granulomatous disease that may affect any organ of the body. The most frequent loci of manifestation are the lungs. However, there are individual cases where bones are affected. The literature describes cases in which swelling or fistula were the first findings of a bone lesion. This is the first case reporting an osteolysis in(More)
The objective of this prospective clinical case series was to confirm the 5-year clinical and radiographic performance of titanium implants occlusally loaded after 12 weeks. Periapical X-rays for quantitative bone level assessment were taken immediately post-surgery, after loading, 6 and 12 months, and 5 years after loading. Pocket depth (PD) and clinical(More)
Nasal chondrocytes (NC) derive from the same multipotent embryological segment that gives rise to the majority of the maxillofacial bone and have been reported to differentiate into osteoblast-like cells in vitro. In this study, we assessed the capacity of adult human NC, appropriately primed towards hypertrophic or osteoblastic differentiation, to form(More)
The gold standard treatment of large segmental bone defects is autologous bone transfer, which suffers from low availability and additional morbidity. Tissue engineered bone able to engraft orthotopically and a suitable animal model for pre-clinical testing are direly needed. This study aimed to evaluate engraftment of tissue-engineered bone with different(More)
Anterior lumbar interbody fusion (ALIF) is a surgical technique used to treat a variety of spinal disorders. Anterior discectomy and fusion allows a direct enhancement of disc height with restoration of lumbar lordosis. This technique also accomplishes an indirect neuroforaminal decompression. Furthermore, anterior interbody spinal fusion is associated with(More)
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