Claude Fortin

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We demonstrate autosomal-recessive Caspase Recruitment Domain-containing protein 9 (CARD9) deficiency in a patient with relapsing C. albicans meningoencephalitis. We identified a novel, hypomorphic mutation with intact Th17 responses, but impaired GM-CSF responses. We report complete clinical remission with adjunctive GM-CSF therapy, suggesting that a(More)
The influence of time, ambient concentration, and medium composition on selenite (Se(IV)) uptake by the unicellular green alga Chlamydomonas reinhardtii has been investigated. The aims of the performed experiments were to describe the kinetics of accumulation, to characterize transport capacities, to identify key nutrients influencing absorption, and to(More)
The effect of core-shell copper oxide nanoparticles with sizes smaller than 100 nm on cellular systems is still not well understood. Documenting these effects is pressing since core-shell copper oxide nanoparticles are currently components of pigments used frequently as antifouling paint protecting boats from crustacean, weed and slime fouling. However, the(More)
The influence of pH and hardness cation concentrations on uranium uptake by a green alga, Chlamydomonas reinhardtii, was investigated through short-term exposure experiments. Uranium uptake at pH 5 and at pH 7 was measured over a large concentration range (0.020-2.0 microM 233U), and the effects of hardness cations were studied over environmentally(More)
The toxicity of selenium in aquatic ecosystems is mainly linked to its uptake and biotransformation by micro-organisms, and its subsequent transfer upwards into the food chain. Thus, organisms at low trophic level, such as algae, play a crucial role. The aim of our study was to investigate the biological effects of selenite on Chlamydomonas reinhardtii,(More)
BACKGROUND Initial reports from observational and randomized trials of uterine endometrial thermal balloon therapy (UBT) suggested good results as judged by return to eumenorrhoea or less and patient satisfaction. Long-term follow-up data remained limited by the small numbers of patients and duration of follow-up. We present long-term (4-6 years) follow-up(More)
OBJECTIVE To evaluate the effects of prior single-layer compared with double-layer closure on the risk of uterine rupture. METHODS A multicenter, case-control study was performed on women with a single, prior, low-transverse cesarean who experienced complete uterine rupture during a trial of labor. For each case, three women who underwent a trial of labor(More)
STUDY OBJECTIVES To evaluate the safety and efficacy of thermal balloon endometrial ablation in women with menorrhagia, and to identify factors influencing outcome. DESIGN Prospective, observational study (Canadian Task Force classification II-2). SETTING Three Canadian university-affiliated teaching hospitals. PATIENTS One hundred twenty-one women(More)
We evaluated the efficacy and tolerability of a single dose of the split virion AS03-adjuvanted pandemic H1N1 influenza vaccine (A/California/7/2009) in 84 HIV-1 infected individuals. Antibody titers were determined by hemagglutination inhibition assay and by microneutralization. Vaccine was well tolerated. At 21 days post vaccination, 56 (67%) patients had(More)
To elicit a biological response from a target organism and/or to accumulate within this organism, a metal must first interact with a cell membrane. For hydrophilic metal species, this interaction with the cell surface can be represented in terms of the formation of M-X-cell surface complexes, e.g. M(z+)+(-)X-cell<-->M-X-cell, where -X-cell is a cellular(More)