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  • Zhou Songyang, Kun Ping Lu, +12 authors Lewis C. Cantley
  • Medicine, Biology
  • Molecular and cellular biology
  • 1996 (First Publication: 1 November 1996)
  • We have developed a method to study the primary sequence specificities of protein kinases by using an oriented degenerate peptide library. We report here the substrate specificities of eight proteinExpand
  • Thierry Buchou, Muriel Vernet, +6 authors Brigitte Boldyreff
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 2003 (First Publication: 1 February 2003)
  • ABSTRACT Protein kinase CK2 is a ubiquitous protein kinase implicated in proliferation and cell survival. Its regulatory β subunit, CK2β, which is encoded by a single gene in mammals, has beenExpand
  • Tania Tahtouh, Jonathan M. Elkins, +13 authors Laurent Meijer
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2012 (First Publication: 8 October 2012)
  • DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's disease and Down syndrome. The marineExpand
  • Mathieu Laramas, Dominique Pasquier, Odile Filhol, François Ringeisen, Jean-Luc Descotes, Claude Cochet
  • Biology, Medicine
  • European journal of cancer
  • 2007 (First Publication: 1 March 2007)
  • Many genomic abnormalities have been identified in various subsets of prostate cancer, but until now, few genes have been associated with the progression of this cancer. High activity of proteinExpand
  • Emmanuelle Huillard, Léa Ziercher, +6 authors Thierry Buchou
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 2010 (First Publication: 5 April 2010)
  • ABSTRACT Genetic programs that govern neural stem/progenitor cell (NSC) proliferation and differentiation are dependent on extracellular cues and a network of transcription factors, which can beExpand