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BACKGROUND Septic shock is frequently complicated by a syndrome of disseminated intravascular coagulation (DIC). Numerous uncontrolled clinical studies have reported that antithrombin III (ATIII) substitution might prevent DIC and death in septic shock. METHODS We conducted a randomized double-blind placebo-controlled trial in patients with a documented(More)
OBJECTIVE To study the dental status and colonization of dental plaque by aerobic pathogens and their relation with nosocomial infections in intensive care unit (ICU) patients. DESIGN A prospective study in a medical ICU of a university-affiliated hospital. PATIENTS Consecutive patients admitted to the ICU during a 3-mo period. INTERVENTIONS Dental(More)
Objectives: To assess the relevance of current monitoring alarms as a warning system in the adult ICU. Design: Prospective, observational study. Settings: Two university hospital, and three general hospital, ICUs. Patients: Hundred thirty-one patients, ventilated at admission, from different shifts (morning, evening, night) combined with different stages of(More)
STUDY OBJECTIVE Our aim was to document the following in patients with septic shock and disseminated intravascular coagulation (DIC): (1) the influence of DIC in the mortality rate and the occurrence of organ failure; (2) the comparative prognostic value of initial antithrombin III (ATIII), protein C (PC), and protein S (PS) levels; and (3) the compared(More)
Objectives: To document in intensive care unit (ICU) patients the effect of dental plaque antiseptic decontamination on the occurrence of plaque colonization by aerobic nosocomial pathogens and nosocomial infections. Design: Single-blind randomized comparative study. Setting: A 16-bed adult intensive care unit in a university hospital. Patients: Patients(More)
To investigate whether the level of initial flow rate alters the work of breathing in chronic obstructive pulmonary disease (COPD) patients ventilated in pressure support ventilation (PSV). Prospective study. Medical ICU in University hospital. Eleven intubated COPD patients. We modulated the initial flow rate in order to achieve seven different sequences.(More)
l s prospectively staslied 15 septic (P) tifio rxptirecl a basal Ibperrire infusion and the addition of a 2nd CH. Initial and final values for PAJP, I-AP, CI, SR, D02 amyl 402 trure assessed before and after tta second drug had started. 311 15 P rere on Lbomrdne (Dl mean close 8,3 t / g/ndn) infusion. Dobutanitle (Le) sea a:kieci in 7 P (group I nenn dose(More)
METHODS Estrone (E1), estradiol (E2), testosterone (T), FSH, and LH levels were daily measured during a ten day period in 50 critically ill patients (38 men, 12 post-menopausal women). Patients were separated into four groups: A) no circulatory failure, no sepsis, B) sepsis syndrome without circulatory failure, C) circulatory failure without sepsis(More)
The field of ventilatory support has changed dramatically with the introduction of improvements in technology and new ventilatory modes. The most recent ventilators are characterized by microprocessor technology, making the interaction between patient and ventilator more sophisticated than ever before. This technology has enabled the development of pressure(More)
Despite intensive therapy, severe septic shock is commonly associated with myocardial dysfunction and death in humans. No new therapies have proven efficiency against cardiovascular alterations in sepsis. Here, we addressed the question of a beneficial effect of pharmacological inhibition of caspases on myocardial dysfunction following endotoxin treatment.(More)