Clarke E Grosvenor

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Research dealing with hormones/growth factors in milk has progressed rapidly during the last 10 yr from their identification in milk to their regulation of various functions in the maternal organism and in the neonate. Many hormones, growth factors, and bioactive substances present in the maternal organism are present in colostrum and milk, often exceeding(More)
Prolactin (PRL) is present in the milk of lactating rats and, when ingested by the pups, can pass through the gut and enter the systemic circulation. The present study tested whether a suppression of normal milk PRL intake by the pups during early postpartum period affects the subsequent level of activity of the tuberoinfundibular dopamine (TIDA) system.(More)
We studied the effect of dopamine (DA) on the rate of processing of PRL after biosynthesis and, with TRH, on the secretion of PRL of different intracellular ages. In these studies anterior pituitary (AP) PRL of lactating rats was pulse labeled either in vivo with [3H]leucine (3 microCi/g BW, injected iv 0.2, 1, 4, 8, 16, or 24 h before removing the AP for(More)
The involvement of pituitary prolactin (PRL) in systemic vasoactive intestinal peptide (VIP)-induced sleep was studied. Male rats were implanted with electrodes for EEG-recording, with brain thermistors to record cortical temperature (Tcrt) and with chronic intracardial catheters to obtain blood samples and to deliver substances. One group of rats (n = 8)(More)
Adrenergic systems exert dual control over the release of oxytocin (OT) in rats, with stimulation of alpha-adrenergic receptors exciting, and stimulation of beta-adrenergic receptors inhibiting, release of this neurohormone. Because suckling stimulation also releases epinephrine from the adrenal medulla, the present experiments tested whether catecholamines(More)
Bromocryptine potently decreased prolactin (PRL) secretion of pituitary glands of 2-day-old rats in vitro (up to 85% inhibition; ED50 between 0.1 and 1.0 nM) without altering the bioactivity to immunoreactivity (B/I) ratio. Bromocryptine tended to suppress growth hormone (GH) secretion although the effect did not reach statistical significance.(More)