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Antagonism of buthionine sulfoximine cytotoxicity for human neuroblastoma cell lines by hypoxia is reversed by the bioreductive agent tirapazamine.
Relapse of neuroblastoma (NB) commonly occurs in hypoxic tissues. Buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) synthesis, is cytotoxic for NB cell lines in atmospheric oxygen (20%Expand
In vitro testing of chemosensitivity in physiological hypoxia.
Highly aggressive, rapidly growing tumors are often hypoxic, owing to an inadequate supply relative to consumption of oxygen (O2) in the expanding tumor mass, or growth in tissues withExpand
The Role of Support Staff in Pediatric Palliative Care: Their Perceptions, Training, and Available Resources
Pediatric palliative care requires the orchestrated efforts of a multidisciplinary care team of medical staff, nursing, psychosocial staff, and other healthcare professionals. Augmenting this teamExpand
STEM-01NEURAL STEM CELL-MEDIATED ENZYME/PRODRUG THERAPY FOR NEUROBLASTOMA: TRANSLATION TO THE CLINIC
Neuroblastoma (NB), a neuroendocrine tumor, is the most common extracranial solid tumor of childhood. 45% of these patients are diagnosed with metastatic high-risk tumors, for which treatment optionsExpand
634. Translation of a Neural Stem Cell-Mediated Enzyme/Prodrug Gene Therapy for Metastatic Neuroblastoma
Neuroblastoma (NB), a neuroendocrine tumor, is the most common extracranial solid tumor of childhood. Forty-five percent of these patients are diagnosed with metastatic high-risk tumors, for whichExpand