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The pattern of retrograde axonal transport of the target-derived neurotrophic molecule, nerve growth factor (NGF), correlates with its trophic actions in adult neurons. We have determined that the NGF-related neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are also retrogradely transported by distinct populations of(More)
In contrast with the prevailing view that most tumors and metastases begin as avascular masses, evidence is presented here that a subset of tumors instead initially grows by coopting existing host vessels. This coopted host vasculature does not immediately undergo angiogenesis to support the tumor but instead regresses, leading to a secondarily avascular(More)
We have investigated the suitability of a recently identified and characterized population of neuronal progenitor cells for their potential use in the replacement of degenerating or damaged neurons in the mammalian brain. The unique population of neuronal progenitor cells is situated in a well-delineated region of the anterior part of the neonatal(More)
Recent chirp seismic reflection data combined with multibeam bathymetry, backscatter, and analysis of grab samples and short cores provide evidence of significant recent erosion on the outer New Jersey shelf. The timing of erosion is constrained by two factors: (1) truncation at the seafloor of what is interpreted to be the transgressive ravinement surface(More)
During the 1964 M9.2 geat Alaskan earthquake, submarine-slope failures resulted in the generation of highly destructive tsunamis at Port Valdez, Alaska. A high-resolution, mini-sparker reflection profiler was used to image debris lobes, which we attribute to slope failures that occurred both during and prior to the 1964 megathrust event. In these reflection(More)
The AMBUR (Analyzing Moving Boundaries Using R) package for the R software environment provides a collection of functions for assisting with analyzing and visualizing historical shoreline change. The package allows import and export of geospatial data in ESRI shapefile format, which is compatible with most commercial and open-source GIS software. The(More)
EXECUTIVE SUMMARY As population pressure increases along the Georgia coast, coastal managers require more and better data regarding coastal resources and human impacts to these resources to carry out their mission, particularly in the expansive and productive salt marshes. Understanding the impact of private recreational docks on saltmarsh ecosystems is(More)
Pleistocene New Jersey shelf sedimentology is strongly influenced by glacially driven sea level changes. A combination of regressive shoreline processes, subaerial exposure, fluvial downcutting, and deposition and reworking during transgression has influenced the NJ shelf sediment composition. Sediment provenance and transport history may be determined on a(More)