Clarisse Simoes

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OBJECTIVE To evaluate the contribution of HLA-DM alleles to susceptibility to systemic lupus erythematosus (SLE) in a Caucasian population. METHODS HLA-DMA and DMB alleles were studied in 73 patients with SLE, 147 randomly selected controls, and 86 HLA-DRB1 genotype matched controls by oligotyping of polymerase chain reaction amplified genomic DNA with(More)
Despite the relevance of the software evolution phase, there are few characterization studies on recurrent evolution growth patterns and on their impact on software properties, such as coupling and cohesion. In this paper, we report a study designed to investigate whether the software evolution categories proposed by Lanza can be used to explain not only(More)
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