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Expression of long-lasting synaptic plasticity and long-term memory requires protein synthesis, which can be repressed by phosphorylation of eukaryotic initiation factor 2 α-subunit (eIF2α). Elevated phosphorylation of eIF2α has been observed in the brains of Alzheimer's disease patients and Alzheimer's disease model mice. Therefore, we tested whether(More)
OBJECTIVE Multiple sclerosis is a neurodegenerative disease characterized by episodes of immune attack of oligodendrocytes leading to demyelination and progressive functional deficit. One therapeutic strategy to address disease progression could consist in stimulating the spontaneous regenerative process observed in some patients. Myelin regeneration(More)
Supplementary Figure 1. PERK conditional knockout (PERK cKO) mice. (a) Western blots showing that levels of PERK and phospho-eIF2α were reduced in the hippocampus of PERK cKO mice, but not in the cerebellum, representative of three independent experiments. (b) Immunofluorescent confocal microscopy revealed the cellular co-localization of PERK and(More)
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