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- Marios Politis, Kit Wu, +6 authors Paola Piccini
- Science translational medicine
- 2010
Troublesome involuntary movements in the absence of dopaminergic medication, so-called off-medication dyskinesias, are a serious adverse effect of fetal neural grafts that hinders the development of… (More)
- Marios Politis, Kit Wu, +6 authors Paola Piccini
- The Journal of clinical investigation
- 2014
Levodopa-induced dyskinesias (LIDs) are the most common and disabling adverse motor effect of therapy in Parkinson's disease (PD) patients. In this study, we investigated serotonergic mechanisms in… (More)
- Marios Politis, Kit Wu, Clare M Loane, Lorenzo Kiferle, Paola Piccini
- Neurobiology of Disease
- 2010
Thirty Parkinson's disease (PD) patients were divided into three equal groups according to their disease duration while 10 normal healthy volunteers matched for age and sex served as a control group.… (More)
- Marios Politis, Kit Wu, +4 authors Paola Piccini
- Neurology
- 2010
BACKGROUND
Depression associated with Parkinson disease (PD) has a different symptom profile to endogenous depression. The etiology of depression in PD remains uncertain though abnormal serotonergic… (More)
- Marios Politis, Clare M Loane, +6 authors Paola Piccini
- Brain : a journal of neurology
- 2013
Hypersexuality with compulsive sexual behaviour is a significant source of morbidity for patients with Parkinson's disease receiving dopamine replacement therapies. We know relatively little about… (More)
- Clare M Loane, Marios Politis
- Brain Research
- 2012
Buspirone is an anxiolytic drug and is a partial agonist for the serotonin 5-HT(1A) receptors as well as possessing low affinity and is an antagonist for the dopamine D(2) autoreceptors, with some… (More)
- Clare M Loane, Marios Politis, +6 authors Paola P Piccini
- Movement disorders : official journal of the…
- 2016
BACKGROUND
Measuring microstructure alterations with diffusion tensor imaging in PD is potentially a valuable tool to use as a biomarker for early diagnosis and to track disease progression. Previous… (More)
- Sean Stephen O'Sullivan, Atbin Djamshidian, Andrew H Evans, Clare M Loane, A. J. Lees, A. D. Lawrence
- Movement disorders : official journal of the…
- 2010
Hoarding is seen in several psychiatric conditions, but has not been specifically assessed in Parkinson's disease (PD). This study investigates hoarding tendency amongst patients with PD, and its… (More)
- Marios Politis, Clare M Loane
- TheScientificWorldJournal
- 2011
Growing evidence suggests that Parkinson's disease is not solely affecting the dopaminergic system. Results from biochemical, animal, postmortem, and functional imaging studies have revealed that… (More)
- Marios Politis, Kit Wu, +6 authors Paola Piccini
- Science translational medicine
- 2012
Cell therapy studies in patients with Parkinson's disease (PD) have been confined to intrastriatal transplantation of dopamine-rich fetal mesencephalic tissue in efforts to improve motor performance.… (More)