Clare L. Littlewood

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Ketamine induces, in both humans and rodents, behaviours analogous to some of the symptoms of schizophrenia. To utilise pharmacological magnetic resonance imaging (phMRI) techniques that identify changes in blood-oxygenation-level-dependent (BOLD) contrast to determine the temporal and spatial neuronal activation profile of ketamine in the rat brain. To(More)
RATIONALE Ketamine is a chiral molecule that is reported to model aspects of schizophrenia. OBJECTIVES To investigate the stereospecificity of the isomers of ketamine using pharmacological magnetic resonance imaging (phMRI) in order to further understand ketamine's pharmacodynamic actions. METHOD Responses to 25 mg kg-1S(+) isomer, R(-) isomer and(More)
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