• Publications
  • Influence
Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task
Various lines of evidence suggest a role in cognition for the endogenous neuropeptide, neurotensin, involving an interaction with the central nervous system cholinergic pathways. A preliminary studyExpand
  • 43
  • 4
Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats
Rationale3,4-methylenedioxymethamphetamine (MDMA, ecstasy) produces an acute release of 5-HT in the brain, together with increased locomotion and hyperthermia.ObjectiveThis study examined whether theExpand
  • 36
  • 3
  • PDF
Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition
Latent inhibition (LI) manifests as poorer conditioning to a CS that has previously been presented without consequence. There is some evidence that LI can be potentiated by reduced mesoaccumbalExpand
  • 21
  • 2
  • PDF
Effects of chronic infusion of neurotensin and a neurotensin NT1 selective analogue PD149163 on amphetamine-induced hyperlocomotion
Neurotensin (NT) has been proposed as an endogenous antipsychotic based in part on the similarity in behavioural effects to antipsychotic drugs, for example, attenuation of both amphetamine-inducedExpand
  • 17
  • 2
Early life programming of fear conditioning and extinction in adult male rats
The early rearing environment programs corticolimbic function and neuroendocrine stress reactivity in adulthood. Although early environmental programming of innate fear has been previously examined,Expand
  • 52
  • 1
Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone
The psychoactive effects of mephedrone are commonly compared with those of 3,4‐methylenedioxymethamphetamine, but because of a shorter duration of action, users often employ repeated administrationExpand
  • 24
  • 1
  • PDF
Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain
Background The mechanisms driving osteoarthritic pain remain poorly understood, but there is increasing evidence for a role of the central nervous system in the chronification of pain. We usedExpand
  • 16
  • 1
  • PDF
Basolateral amygdala activity during the retrieval of associative learning under anesthesia
Associative learning can occur under anesthesia and its neural correlates have begun to be elucidated. During discrimination learning under anesthesia in rats, lateral amygdala excitability increasesExpand
  • 18
  • 1
  • PDF
Systemic administration of WY-14643, a selective synthetic agonist of peroxisome proliferator activator receptor-alpha, alters spinal neuronal firing in a rodent model of neuropathic pain
Abstract Background and aims The clinical management of chronic neuropathic pain remains a global health challenge. Current treatments are either ineffective, or associated with unwantedExpand
  • 2
  • 1
Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht6 receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task
RationaleSelective 5-ht6 receptor antagonists like Ro 04-6790 prolong memory in many rodent preclinical paradigms, possibly by blocking tonic 5-HT-evoked GABA release and allowing disinhibition ofExpand
  • 29