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BACKGROUND This is the first report on the epidemiology of depressive disorders from the European Outcome of Depression International Network (ODIN) study. AIMS To assess the prevalence of depressive disorders in randomly selected samples of the general population in five European countries. METHOD The study was designed as a cross-sectional two-phase(More)
OBJECTIVES To determine the acceptability of two psychological interventions for depressed adults in the community and their effect on caseness, symptoms, and subjective function. DESIGN A pragmatic multicentre randomised controlled trial, stratified by centre. SETTING Nine urban and rural communities in Finland, Republic of Ireland, Norway, Spain, and(More)
OBJECTIVES To undertake a prospective epidemiological study of the injuries sustained in English professional football over two competitive seasons. METHODS Player injuries were annotated by club medical staff at 91 professional football clubs. A specific injury audit questionnaire was used together with a weekly form that documented each club's current(More)
AIM This paper is a report of a systematic review of the effectiveness and cost-effectiveness of nurse-led follow-up for patients with cancer. BACKGROUND As cancer survivorship increases, conventional follow-up puts a major burden on outpatient services. Nurse-led follow-up is a promising alternative. Data sources. Searches were conducted covering a(More)
Triclinic crystals of lysozyme, hydrogen-deuterium exchanged in deuterated solvent, have been studied using neutron quasi-Laue techniques and a newly developed cylinder image-plate detector. The wavelength range employed was from 2.7 to 3.5 A, which gave 9426 significant reflections [F >/= 2sigma(F)] to a resolution limit of 1. 7 A. The deuteration states(More)
Integral membrane proteins are solubilized by their incorporation into a detergent micelle. The detergent micelle has a critical influence on the formation of a three-dimensional crystal lattice. The bulk detergent phase is not seen in X-ray crystal structures of integral membrane proteins, due to its disordered character. Here, we describe the detergent(More)
BACKGROUND Spinal pain is common and frequently disabling. Management guidelines have encouraged referral from primary care for spinal manipulation. However, the evidence base for these recommendations is weak. More pragmatic trials and economic evaluations have been recommended. OBJECTIVES Our aim was to assess the effectiveness and health care costs of(More)
BACKGROUND Assisted dying is legal in four European countries and three American states. Elsewhere, particularly in more affluent or mainly Protestant countries, it remains controversial. Dominant headlines feature professional (medical, legal, religious) arguments versus celebrity campaigners; ordinary people are less clearly represented. AIM To(More)
BACKGROUND Cancer follow-up places a significant burden on hospital outpatient clinics. There are increasing calls to develop alternative models of provision. AIM To undertake a systematic review of qualitative studies examining patients' and healthcare professionals' views about cancer follow-up. DESIGN OF STUDY Systematic review. SETTING Primary and(More)
BACKGROUND Osteoarthritis (OA) of the knee is common and disabling. Exercise is effective in reducing pain and disability, but long-term adherence to exercise regimens is disappointing, and motivation to exercise in those with OA knee is poorly understood. OBJECTIVES To examine the views of primary care patients with OA knee towards exercise, explore(More)